Results 61 to 70 of about 45,242 (261)

Identification of Potential Vectors and Species Density of Tsetse Fly, Prevalence, and Genetic Diversity of Drug-Resistant Trypanosomes in Kenya

Pathogens
Tsetse flies are major vectors of trypanosomes in Sub-Saharan Africa, posing risks to livestock and human health. This study investigated the diversity, distribution, and infection rates of tsetse species, as well as the genetic diversity of drug ...
Ivy S. Okello, Samuel G. Onyoyo, Isaiah N. Kiteto, Sylvia M. Korir, Seth. O. Onyango   +4 more
doaj   +1 more source

4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei

Microorganisms, 2021
Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment.
Dorien Mabille, Camila Cardoso Santos, Rik Hendrickx, Mathieu Claes, Peter Takac, Christine Clayton, Sarah Hendrickx, Fabian Hulpia, Louis Maes, Serge Van Calenbergh, Guy Caljon   +10 more
doaj   +1 more source

Animal Trypanosomiasis: Challenges and Prospects for New Vaccination Strategies

Microorganisms
Animal trypanosomiasis, such as nagana, surra, and dourine, represent a significant challenge to animal health and economic development, especially in tropical and subtropical regions where livestock production is an essential component of a country’s ...
Samille Henriques Pereira, F. P. Alves, S. Teixeira   +2 more
semanticscholar   +1 more source

Eflornithine is Safer Than Melarsoprol for the Treatment of Second-Stage Trypanosoma Brucei Gambiense Human African Trypanosomiasis. [PDF]

, 2005
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
Chappuis, F, Udayraj, N, Meussen, A, Bovier, P A, Stietenroth, K, Meussen A, Bovier PA, Chappuis F, Udayraj N, Stietenroth K   +9 more
core   +1 more source

Design and Synthesis of Cysteine Proteases Inhibitors

Proceedings, 2019
Cysteine proteases belonging to the papain superfamily have been recognized as interesting therapeutic targets for the search for new drugs against infectious tropical diseases such as malaria (falcipain), Chagas’ disease (curtain), leishmaniasis, and ...
Florenci V. Gonzalez
doaj   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice.

Lancet. Infectious Diseases (Print), 2019
Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a parasitic infection that usually progresses to coma and death unless treated.
A. Lindner, V. Lejon, F. Chappuis, J. Seixas, L. Kazumba, M. Barrett, Erick Mwamba, Olema Erphas, E. Akl, Gemma Villanueva, H. Bergman, P. Simarro, Augustin Kadima Ebeja, G. Priotto, J. Franco   +14 more
semanticscholar   +1 more source

From sentinel surveillance for sleeping sickness treatment failure to the development of a pharmacovigilance approach [PDF]

, 2011
In the late 1990’s a disturbing trend of geographically distinct melarsoprol treatment failures accompanied a dramatic resurgence of Human African Trypanosomiasis.
Dahl, Benjamin Arthur
core   +1 more source

Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity

Molecules, 2018
Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature.
Maureen Gumbo, Richard M. Beteck, Tawanda Mandizvo, Ronnett Seldon, Digby F. Warner, Heinrich C. Hoppe, Michelle Isaacs, Dustin Laming, Christina C. Tam, Luisa W. Cheng, Nicole Liu, Kirkwood M. Land, Setshaba D. Khanye   +12 more
doaj   +1 more source

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source