Results 51 to 60 of about 45,242 (261)

Discovery, Development, Inventions and Patent Review of Fexinidazole: The First All-Oral Therapy for Human African Trypanosomiasis

Pharmaceuticals, 2022
Human African trypanosomiasis (HAT or ‘sleeping sickness’) is a neglected tropical disease. If untreated, it is always fatal and leads to death. A few treatments are available for HAT, but most of them require a skilled professional, which increases the ...
Mohd Imran, Shah Alam Khan, Mohammed Kanan Alshammari, Ashwaq Muiedh Alqahtani, Turkiah Abdullah Alanazi, Mehnaz Kamal, Talha Jawaid, Mohammed M. Ghoneim, Sultan Alshehri, Faiyaz Shakeel   +9 more
doaj   +1 more source

Fexinidazole as a new oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a prospective, open-label, single-arm, phase 2-3, non-randomised study.

Lancet Global Health
BACKGROUND Rhodesiense human African trypanosomiasis is a neglected disease with epidemic potential that can rapidly become lethal if left untreated. The aim of this study was to show that fexinidazole could offer an alternative to existing treatments ...
E. Matovu, Westain T. Nyirenda, Anthony Eriatu, D. Alves, Christelle Perdrieu, M. Lemerani, C. Wamboga, V. Lejon, J. Seixas, Aita Signorell, Anne Reymondier, E. Baudin, Bruno Scherrer, Olaf Valverde Mordt   +13 more
semanticscholar   +1 more source

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System

Pathogens, 2021
Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T.
Stefan Magez, Joar Esteban Pinto Torres, Seoyeon Oh, Magdalena Radwanska   +3 more
doaj   +1 more source

New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine.

Lancet. Infectious Diseases (Print)
Human African trypanosomiasis is a neglected tropical disease that is usually fatal without treatment. WHO has revised its rhodesiense human African trypanosomiasis treatment guidelines on the basis of an independent systematic literature review and ...
Andreas K. Lindner, V. Lejon, Michael P. Barrett, L. Blumberg, Salome A. Bukachi, R. Chancey, Andrew Edielu, Lucas E Matemba, Tihitina Mesha, V. Mwanakasale, C. Pasi, T. Phiri, J. Seixas, E. Akl, K. Probyn, Gemma Villanueva, P. Simarro, Augustin Kadima Ebeja, J. Franco, G. Priotto   +19 more
semanticscholar   +1 more source

THE TREATMENT OF TRYPANOSOMIASIS. [PDF]

The Lancet, 1907
n ...
openaire   +2 more sources

Shifting livelihood strategies in northern Nigeria - extensified production and livelihood diversification amongst Fulani pastoralists

Pastoralism, 2017
This paper presents an in-depth investigation of the livelihood strategies of Fulani pastoralists in north central Nigeria. Results show a diversified crop-livestock system aimed at spreading risk and reducing cattle offtake, adapted to natural resource ...
Ayodele O. Majekodunmi, Charles Dongkum, Tok Langs, Alexandra P. M. Shaw, Susan C. Welburn   +4 more
doaj   +1 more source

Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital—Clinical Features of Patients with Positive Screening Serologic Testing

Tropical Medicine and Infectious Disease, 2021
Chagas disease (CD) is the third most common parasitic infection globally and can cause cardiac and gastrointestinal complications. Around 300,000 carriers of CD live in the U.S., with about 3000 of those in Colorado.
Peter Hyson, Lilian Vargas Barahona, Laura C. Pedraza-Arévalo, Jonathan Schultz, Luisa Mestroni, Maria da Consolação Moreira, Matthew Taylor, Carlos Franco-Paredes, Esther Benamu, Poornima Ramanan, Anis Rassi, Kellie Hawkins, Andrés F. Henao-Martínez   +12 more
doaj   +1 more source

Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis

Frontiers in Immunology, 2019
Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries. The disease, caused by protozoan parasites of the Trypanosoma genus, is a major cause of mortality and morbidity in animals and man. Human African trypanosomiasis (HAT),
P. Kennedy, J. Rodgers
semanticscholar   +1 more source

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

bioRxiv, 2020
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations.
M. Sterkel, L. Haines, Aitor Casas-Sánchez, Vincent Owino Adung'a, Raquel J. Vionette-Amaral, Shannon Quek, C. Rose, M. Silva dos Santos, Natalia García Escude, H. Ismail, M. Paine, S. Barribeau, S. Wagstaff, J. MacRae, D. Masiga, L. Yakob, P. Oliveira, Á. Acosta-Serrano   +17 more
semanticscholar   +1 more source

Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys [PDF]

, 2015
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of ...
Wang, Michael Z., Shelley Ching, Bridges, Arlene S., Bridges, Arlene S, Wang, Michael Z, Gem, Charles O, Michael Z Wang, Wolf, Kristina K, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Mutuku, James N., Arlene S Bridges, Boykin, David W, Murilla, Grace A, Murilla, Grace A., Qiang Liu, Paine, Mary F., Boykin, David W., Grace A Murilla, Jones, Susan K, Charles O Gem, James N Mutuku, Mary F Paine, Susan K Jones, Richard R Tidwell, Mutuku, James N, Paine, Mary F, David W Boykin, Liu, Qiang, Tidwell, Richard R., John K Thuita, Gem, Charles O., Kristina K Wolf, Jones, Susan K., Brun, Reto, Thuita, John K., Boykin, David, Reto Brun, Piane, Mary F., Tidwell, Richard R, Thuita, John K, Mutuku JN, Ching S, Wolf KK, Brun Reto, Mutuku James N., Bridges AS, Gem CO, Tidwell RR, Boykin DW, Paine MF, Bridges Arlene S., Ching Shelley, Murilla GA, Tidwell Richard R., Liu Q, Wang MZ, Boykin David W., Thuita JK, Gem Charles O., Liu Qiang, Jones SK, Jones Susan K., Brun R, Wang Michael Z., Murilla Grace A., Wolf Kristina K., Thuita John K., Paine Mary F.   +69 more
core   +2 more sources