Results 31 to 40 of about 27,075 (226)

Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys [PDF]

, 2015
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of ...
Wang, Michael Z., Shelley Ching, Bridges, Arlene S., Bridges, Arlene S, Wang, Michael Z, Gem, Charles O, Michael Z Wang, Wolf, Kristina K, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Mutuku, James N., Arlene S Bridges, Boykin, David W, Murilla, Grace A, Murilla, Grace A., Qiang Liu, Paine, Mary F., Boykin, David W., Grace A Murilla, Jones, Susan K, Charles O Gem, James N Mutuku, Mary F Paine, Susan K Jones, Richard R Tidwell, Mutuku, James N, Paine, Mary F, David W Boykin, Liu, Qiang, Tidwell, Richard R., John K Thuita, Gem, Charles O., Kristina K Wolf, Jones, Susan K., Brun, Reto, Thuita, John K., Boykin, David, Reto Brun, Piane, Mary F., Tidwell, Richard R, Thuita, John K   +41 more
core   +1 more source

Diversity and phylogenetic relationships of Glossina populations in Nigeria and the Cameroonian border region

BMC Microbiology, 2018
Background Tsetse flies are vectors of trypanosomes, parasites that cause devastating disease in humans and livestock. In the course of vector control programmes it is necessary to know about the Glossina species present in the study area, the population
Stephen Saikiu Shaida, Judith Sophie Weber, Thaddeus Terlumun Gbem, Sen Claudine Henriette Ngomtcho, Usman Baba Musa, Mbunkha Daniel Achukwi, Mohammed Mamman, Iliya Shehu Ndams, Jonathan Andrew Nok, Soerge Kelm   +9 more
doaj   +1 more source

Camel Trypanosomiasis “Dhukaan” in Lower Juba Region of Somalia: Importance and Microscopic Survey [PDF]

Journal of Applied Veterinary Sciences, 2023
Camel trypanosomiasis is the most significant animal disease in the camel zone of Somalia. The Somali camel is also found in the southern areas of Somalia, which have a high density of vectors, including Glossina.
Abdirazack Osman, Abdisalam Ali, Abdalla Ibrahim   +2 more
doaj   +1 more source

A study of genetic markers in the South African Blesbok (Damaliscus Dorcas Phillipsi)

Koedoe: African Protected Area Conservation and Science, 1972
During culling operations on blesbok from the Rietvlei Nature Reserve, 198 blood samples were obtained for study of genetic markers including haemoglobins, transferrins, amylases, albumins and carbonic anhydrases.
D. R Osterhoff, I. S Ward-Cox, Valerie Emslie   +2 more
doaj   +1 more source

Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis.

, 2011
Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and typically include a screening (serological), confirmation ...
Francesco Checchi, Gerardo Priotto, Daniel Chandramohan, Checchi Francesco, Unni Karunakara, Priotto Gerardo, Checchi, F, Priotto, Gerardo, Priotto, G, Checchi, Francesco, Chappuis, F, Chandramohan, D, Chandramohan, Daniel, Karunakara Unni, François Chappuis, Karunakara, U, Karunakara, Unni, Chappuis, François, Chappuis François, Chandramohan Daniel   +19 more
core   +1 more source

Tsetse and Trypanosomoses in Ghana in the Twentieth Century: a Review

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2003
African animal trypanosomosis, transmitted by tsetse flies (Glossina spp.) is a major constraint limiting the optimal utilization of land for agricultural production in tsetse-infested areas of Ghana.
C. Mahama, H.A. Mohammed, M. Abavana, I. Sidibé, A. Koné, S. Geerts   +5 more
doaj   +1 more source

Discovery, Development, Inventions and Patent Review of Fexinidazole: The First All-Oral Therapy for Human African Trypanosomiasis

Pharmaceuticals, 2022
Human African trypanosomiasis (HAT or ‘sleeping sickness’) is a neglected tropical disease. If untreated, it is always fatal and leads to death. A few treatments are available for HAT, but most of them require a skilled professional, which increases the ...
Mohd Imran, Shah Alam Khan, Mohammed Kanan Alshammari, Ashwaq Muiedh Alqahtani, Turkiah Abdullah Alanazi, Mehnaz Kamal, Talha Jawaid, Mohammed M. Ghoneim, Sultan Alshehri, Faiyaz Shakeel   +9 more
doaj   +1 more source

The Pathogenesis of African Trypanosomiasis

Annual Review of Pathology: Mechanisms of Disease, 2023
African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have developed strategies to continuously escape innate and adaptive responses of the immune system, while also ...
Pays, Etienne, Radwanska, Magdalena, Magez, Stefan   +2 more
openaire   +3 more sources

Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Carol A. Olson (1807531), Patrick D Yeramian, Bilenge, Constantin Miaka Mia, Pascal Lutumba, Manuel, F, Sonja C Bernhard, Allen, James L., Mpanya, Alain, Alain Mpanya, Blum, Johannes, Lubaki, J P, Richard R Tidwell, Gabriele Pohlig, Constantin Miaka Mia Bilenge, Yeramian, Patrick D., Kazadi Kyanza Serge, Tidwell, R R, Thompson, Mark, Alfred Mpoo Mpoto, Bernhard, Sonja C., Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Sonja C. Bernhard (1807537), Blaise Fungula Munungu, Bernhard, S C, James L Allen, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Francisco Manuel (1807528), Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Lutumba, P, Pohlig, G, Mark Thompson, Francisco Manuel, Blaise Fungula Munungu (1807519), Merolle, Ada, Lutumba, Pascal, Ada Merolle, Mpoto, Alfred Mpoo, Mesu, V K, Christian Burri, Jean-Pierre Fina Lubaki (1807546), Allen, J L, Josenando, Théophilo, Ada Merolle (1807540), Johannes Blum, Josenando, T, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Bilenge, C M, Blum, J, Manuel, Francisco, Merolle, A, Mesu, Victor Kande Betu Ku, Yeramian, P D, Alfred Mpoo Mpoto (1807534), Serge, K K, Munungu, B F, Alain Mpanya (267142), Mark Thompson (533940), James L. Allen (1807522), Olson, C A, Johannes Blum (141240), Mpoto, A M, Victor Kande Betu Ku Mesu (1807510), Théophilo Josenando (1807516), Mpanya, A, Thompson, M, Patrick D. Yeramian (1807543), Richard R. Tidwell (148409), Théophilo Josenando, Burri, C, Jean-Pierre Fina Lubaki, Serge, Kazadi Kyanza, Kazadi Kyanza Serge (1807525), Pascal Lutumba (116142)   +79 more
core   +1 more source

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System

Pathogens, 2021
Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T.
Stefan Magez, Joar Esteban Pinto Torres, Seoyeon Oh, Magdalena Radwanska   +3 more
doaj   +1 more source