Results 71 to 80 of about 27,075 (226)

Human African trypanosomiasis

, 2009
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies.
Chappuis, F, Blum, J., Brun, R, Chappuis, F., Brun, R., Burri, C, Burri, C., Blum, J   +7 more
core   +1 more source

Nifurtimox plus eflornithine for late-stage sleeping sickness in Uganda: A case series [PDF]

, 2007
Background: We report efficacy and safety outcomes from a prospective case series of 31 late-stage T. b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+ E) in Yumbe ...
Thomas, F, Legros, Dominique, Francesco Checchi, Patrice Piola, Thomas Florence, Ayikoru Harriet, Gerardo Priotto, Piola, P, Ayikoru, H, Piola, Patrice, Ayikoru, Harriet, Checchi Francesco, Legros, D, Thomas, Florence, Priotto Gerardo, Checchi, F, Priotto, Gerardo, Florence Thomas, Priotto, G, Checchi, Francesco, Legros Dominique, Dominique Legros, Harriet Ayikoru, Piola Patrice   +23 more
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Trypanocidal Essential Oils: A Review

Molecules, 2020
Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis.
Mayara Castro de Morais, Jucieudo Virgulino de Souza, Carlos da Silva Maia Bezerra Filho, Silvio Santana Dolabella, Damião Pergentino de Sousa   +4 more
doaj   +1 more source

Addressing Climate Driven Vector‐Borne Disease in West Africa

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Vector‐borne diseases (VBDs) pose a significant public health threat in West Africa, contributing to substantial morbidity and mortality, particularly among vulnerable populations. This region is highly susceptible to the effects of climate change due to its geographical location, dependence on rain‐fed agriculture, and fragile ...
Majani Edward, Oladipupo Iyanu Roseline, Emmanuel Victor, Oladeji Yinmi Gabriel   +3 more
wiley   +1 more source

Implications of heterogeneous biting exposure and animal hosts on Trypanosomiasis brucei gambiense transmission and control [PDF]

, 2015
The gambiense form of sleeping sickness is a neglected tropical disease, which is presumed to be anthroponotic. However, the parasite persists in human populations at levels of considerable rarity and as such the existence of animal reservoirs has been ...
Chitnis, Nakul, Nakul Chitnis (187823), Stone, Chris M., Nakul Chitnis, Chris M Stone, Chris M. Stone (802289)   +5 more
core   +1 more source

Leptin Functions in Infectious Diseases

Frontiers in Immunology, 2018
Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and ...
Radheshyam Maurya, Parna Bhattacharya, Ranadhir Dey, Hira L. Nakhasi   +3 more
doaj   +1 more source

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis [PDF]

, 2010
<p><b>Background:</b> <i>Trypanosoma brucei gambiense</i> is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central ...
Martin A Aslett, Hertz-Fowler Christiane, Chukualim, B., Gibson, W., Melville, S.E., Jackson Andrew P., Jackson, A.P., Jackson, A., Capewell, P., Sanders Mandy, Annette MacLeod, McQuillan, J, Quail, M.A., MacLeod Annette, Melville Sara E., Melville, S., McQuillan, J., Paul Capewell, Aslett Martin A., Bridget Chukualim, MacLeod, A., Aslett, M., Hertz-Fowler, C., McQuillan Jacqueline, Aslett, M.A., Mandy Sanders, Berry Andrew, Michael A Quail, Barry, J.D., Berriman, M., Sanders, M., Wendy Gibson, Sara E Melville, Jacqueline McQuillan, Gibson, WC, Quail Michael A., Berry, A., J David Barry, Andrew P Jackson, Andrew Berry, Christiane Hertz-Fowler, Matthew Berriman, Chukualim Bridget, Gibson Wendy, Barry J. David, Capewell Paul, Berriman Matthew   +46 more
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Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Bayesian geostatistical analysis and prediction of Rhodesian human African trypanosomiasis

, 2010
BackgroundThe persistent spread of Rhodesian human African trypanosomiasis (HAT) in Uganda in recent years has increased concerns of a potential overlap with the Gambian form of the disease.
Fevre, Eric M., Welburn Susan C., Peter M Atkinson, Kakembo, A.S., Peter W Gething, Kakembo, Abbas S. L., Susan C Welburn, Wardrop, Nicola A., Peter W. Gething, Picozzi, K., Picozzi, K, Atkinson Peter M., Nicola A. Wardrop, Gething, Peter W., Peter M. Atkinson, Susan C. Welburn, Fèvre Eric M., Picozzi, Kim, Kakembo, Abbas S.L., Kakembo, AS, Wardrop, N.A., Eric M. Fèvre, Gething, PW, Gething, P.W., Eric M Fèvre, Fèvre, EM, Kakembo, ASL, Wardrop Nicola A., Kakembo Abbas S. L., Wardrop, NA, Abbas S L Kakembo, Nicola A Wardrop, Welburn, SC, Atkinson, PM, Kim Picozzi, Picozzi Kim, Atkinson, Peter M., Welburn, Susan C., Atkinson, P.M., Abbas S. L. Kakembo, Gething Peter W.   +40 more
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Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source