Interactive molecular dynamics in virtual reality for accurate flexible protein-ligand docking [PDF]
, 2019 Simulating drug binding and unbinding is a challenge, as the rugged energy landscapes that separate bound and unbound states require extensive sampling that consumes significant computational resources. Here, we describe the use of interactive molecular dynamics in virtual reality (iMD-VR) as an accurate low-cost strategy for flexible protein-ligand ...
arxiv +1 more source
The Spreading of Pepsin and of Trypsin [PDF]
Journal of General Physiology, 1935 In this article the behavior of pepsin and trypsin in a monolayer under various conditions will be described. Both substances1 show all the characteristic properties of other proteins. Pepsin is admirably suited for the study of the influence of positive ions, as its isoelectric point lies far to the acid side. On trypsin the influence of negative ions
openaire +3 more sources
Cis-mediated down-regulation of a trypsin gene associated with Bt resistance in cotton bollworm
Scientific Reports, 2014 Transgenic plants producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) are useful for pest control, but their efficacy is reduced when pests evolve resistance.
Chenxi Liu +5 more
semanticscholar +1 more source
Structural analysis of Salmonella enterica effector protein SopD [PDF]
, 2004 Salmonella outer protein D (SopD) is a type III secreted virulence effector protein from Salmonella enterica. Full-length SopD and SopD lacking 16 amino acids at the N-terminus (SopDDeltaN) have been expressed as fusions with GST in Escherichia coli ...
Bagby, S +7 more
core +1 more source
Novel Phenotypes and Deep Intronic Variant Expand TH‐Associated Dopa‐Responsive Dystonia Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Approximately 20% of dopa‐responsive dystonia (DRD) cases remain genetically unresolved. Using whole‐genome sequencing, we identified two TH variants in a young DRD patient, including a novel deep intronic variant. Minigene assays confirmed that this variant causes aberrant splicing.
Xiaosheng Zheng +6 more
wiley +1 more source
Thermolysin in human cultured keratinocyte isolation
Brazilian Journal of BiologyBACKGROUND: When treating extensively burned patients using cultured epidermal sheets, the main problem is the time required for its production. Conventional keratinocyte isolation is usually done using Trypsin. We used a modification of the conventional
A. Gragnani, CS. Sobral, LM. Ferreira
doaj +1 more source
Проблемы особо опасных инфекций, 2012 The comparative experiments demonstrated strong correlation between the index of Yersinia pestis EV NIIEG strain adhesion to human red blood cells and hydrophobic properties of bacteria.
E. V. Pimenov +2 more
doaj +1 more source
Characterisation of serine proteinase inhibitors in dry seeds of cultivated pasture grass species : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Plant Biology and Biotechnology at Massey University, Palmerston North, New Zealand [PDF]
, 1994 Content removed due to copyright restriction: Tasneem, M., Cornford, C. A., & McManus, M. T. (1994). Characterization of serine proteinase inhibitors in dry seeds of cultivated pasture grass species. Seed Science Research, 4(3), 335-345.
Tasneem, Mohammad
core
Failure to remove bluetongue serotype 8 virus (BTV-8) from in vitro produced and in vivo derived bovine embryos and subsequent transmission of BTV-8 to recipient cows after embryo transfer [PDF]
, 2019 The behavior of BTV-8 in cattle is different from most other serotypes not only with regards to clinical signs but certainly with respect to virus transmission (transplacental, contact). Therefore, the possibility of virus transmission by means of embryo
De Clercq, Kris +6 more
core +1 more source
Journal of Biological Chemistry, 2014 Background: Proteolysis is required for ENaC activity, but the proteases activating ENaC in epithelial tissues are unknown. Results: Human trypsin IV and trypsin I activate ENaC by cleavage at distinct sites in the channel's γ-subunit.
S. Haerteis +11 more
semanticscholar +1 more source