Results 151 to 160 of about 736,972 (389)

Towards a Quantitative Description of Proteolysis: Contribution of Demasking and Hydrolysis Steps to Proteolysis Kinetics of Milk Proteins

open access: yesFoods
The hydrolysis of proteins by proteases (proteolysis) plays a significant role in biology and food science. Despite the importance of proteolysis, a universal quantitative model of this phenomenon has not yet been created.
Mikhail M. Vorob’ev
doaj   +1 more source

TRYPSIN IN MALIGNANT GROWTHS. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1906
ABSTRACT Following the experiments of Beard of Edinburgh with the use of trypsin in Jensen tumors in mice and his suggestion for the use of trypsin in carcinoma, many attempts undoubtedly are being made at present with trypsin in inoperable malignant growths.
openaire   +2 more sources

Self‐Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere‐Aggregated Hydrogels in Triple‐Negative Breast Cancer Therapy

open access: yesAdvanced Functional Materials, EarlyView.
Hyaluronic acid‐dopamine‐based intra‐crosslinked microsphere including cisplatin (HPC MS) is fabricated by spray‐drying and calcium/iron ions are introduced for interparticle crosslinking. Designed microsphere‐aggregated hydrogel (MAH) system including cisplatin/CaO2/FeSO4 can provide apoptosis/calcicoptosis/ferroptosis‐mediated chemo/cascade ...
ChaeRim Hwang   +6 more
wiley   +1 more source

High-affinity binding sites involved in the import of porin into mitochondria [PDF]

open access: yes, 1987
The specific recognition by mitochondria of the precursor of porin and the insertion into the outer membrane were studied with a radiolabeled water-soluble form of porin derived from the mature protein.
Neupert, Walter, Pfaller, Rupert
core   +1 more source

Discovery of PD-L1 Peptide Inhibitors from Ascidian Enzymatic Hydrolysates by Affinity Ultrafiltration Coupled to NanoLC-MS/MS

open access: yesMarine Drugs
Anti-PD-1 and anti-PD-L1 antibodies have achieved great clinical success in cancer immunotherapy, and peptide and small molecule inhibitors of PD-1/PD-L1 binding also attract much attention.
Qiuyang Huang   +7 more
doaj   +1 more source

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

open access: yesAdvanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou   +2 more
wiley   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

open access: yesAdvanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen   +13 more
wiley   +1 more source

Identification of a new trypsin from Spodoptera frugiperda involved in a defensive mechanism against the Bacillus thuringiensis Cry1Ca1 toxin

open access: yesBiotecnología Aplicada
Both, insecticidal formulations based on the entomopathogenic bacterium Bacillus thuringiensis (Bt) and transgenic plants expressing Bt Cry toxins, have been threatened by the potential appearance of insect resistance in major crop pests. With the aim of
Lianet Rodríguez   +6 more
doaj  

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