Results 201 to 210 of about 476,853 (295)

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome. [PDF]

Gut
Jimenez-Vargas NN, Sokrat B, Gilmor DA, Fialho MFP, Guzman-Rodriguez M, Nakhle R, Shi Y, Davidson S, Schmidt BL, Reed DE, Lomax AE, Vanner SJ, Bunnett NW.   +12 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Chemical and Functional Characterization of a Novel European Black Soybean Variety. [PDF]

Molecules
Zdaniewicz M, Lekowski S, Mickowska B, Kowalski S, Makarewicz M.   +4 more
europepmc   +1 more source

Basal pancreatic secretion in a comparative aspect in poultry and rodents

Frontiers in Physiology
Irina V. Kuzmina, Svetlana M. Tolpygo, Alexander V. Kotov, Batogab B. Shoibonov, Tatyana S. Zamolodchikova   +4 more
doaj   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Correction to "Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting With Sustained Mechanical Memory". [PDF]

Adv Healthc Mater
europepmc   +1 more source

New determinant of influenza hemagglutinin cleavability identified through random mutagenesis for acid-stabilizing mutations. [PDF]

Microbiol Spectr
Rimaux S, Oliva MF, Mestdagh C, Van Berwaer R, Chen J, Schurmans L, Schoofs G, Vanmechelen B, Stroobants J, Jacquemyn M, Laporte M, Maes P, Vermeire K, Das K, Stevaert A, Naesens L.   +15 more
europepmc   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

In Vitro Anti-Inflammatory Activity of Sour Cherry (Prunus cerasus L.) Seed Oil and Computational Safety Profiling. [PDF]

Chem Biodivers
Aydin T, Günbatan T, Berkkan A, Ulutaş OK, Sucu M.   +4 more
europepmc   +1 more source