Results 241 to 250 of about 3,264,535 (355)
Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface
Advanced Science, EarlyView.This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu +12 more
wiley +1 more source
Crystal structure of Kunitz-type trypsin inhibitor: Entomotoxic effect of native and encapsulated protein targeting gut trypsin of Tribolium castaneum Herbst. [PDF]
Comput Struct Biotechnol JMehmood S +11 more
europepmc +1 more source
Antimicrobial and antibiofilm activities of Inga cylindrica trypsin inhibitor
Ana Paula Ramos Pereira +6 more
openalex +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors [PDF]
, 1976 Fink, Edwin +5 more
core
Advanced Science, EarlyView.This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji +8 more
wiley +1 more source
Trypsin-Plasmin Inhibitors from Leeches Isolation, Amino Acid Composition, Inhibitory Characteristics [PDF]
, 1971 Fink, Edwin +3 more
core
Nutritional Evaluation of Soybeans Varying in Trypsin Inhibitor Content
, 1991 Yanming Han, C.M. Parsons, T. Hymowitz
openalex +1 more source
Advanced Science, EarlyView.This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang +15 more
wiley +1 more source