Results 241 to 250 of about 353,545 (343)

Scaffold stability and P14' residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4. [PDF]

Biosci Rep, 2022
Walvekar VA, Ramesh K, Kannan M, Kini RM, Sivaraman J, Mok YK.   +5 more
europepmc   +1 more source

Kinetics of the reaction between trypsin and the pancreatic trypsin inhibitor [PDF]

Biochemical Journal, 1957
openaire   +3 more sources

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Crystal structure of Kunitz-type trypsin inhibitor: Entomotoxic effect of native and encapsulated protein targeting gut trypsin of Tribolium castaneum Herbst. [PDF]

Comput Struct Biotechnol J
Mehmood S, Thirup SS, Ahmed S, Bashir N, Saeed A, Rafiq M, Saeed Q, Najam-Ul-Haq M, Khaliq B, Ibrahim M, Alonazi WB, Akrem A.   +11 more
europepmc   +1 more source

Evaluation of morphology and angiogenesis of breast cancer in BALB/c mice using trypsin inhibitor from Cucumis melo seeds. In vitro and in vivo study. [PDF]

Contemp Oncol (Pozn), 2022
Rezaei S, Azarpira N, Koohpeyma F, Yousefi R, Doaei S, Heidari M, Gholamalizadeh M, Haghshenas MR, Mazloom Z.   +8 more
europepmc   +1 more source

A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Overcoming EGFR‐TKI resistance remains a critical challenge in NSCLC treatment. This study identifies CMTM6 as a key regulator of EGFR stability and demonstrates that a novel anti‐CMTM6 nanobody disrupts the CMTM6‐EGFR interaction. Targeting CMTM6 restores EGFR degradation, suppresses tumor growth, and confers therapeutic benefit in both CDX and PDX ...
Lu Xia, Jichuan Wang, Hui Xue, Haimeng Li, Qinghua Li, Sen Qin, Chunyu Yu, Yanhua Liu, Yu Gao, Lingyun Li, Sudun Guan, Enrun Zheng, Feiya Suo, Lin He, Yongsheng Wang, Wenling Han, Yongfeng Shang, Yong Geng, Luyang Sun   +18 more
wiley   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Discovery, identification and mechanism of chemosensitivity-relate biomarker inter-α-trypsin inhibitor heavy chain 4 in metastatic colorectal cancer. [PDF]

Heliyon
Zhao Y, Shen H, Wu J, Yu J, Yuan Y, Zhong C.   +5 more
europepmc   +1 more source

Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors [PDF]

, 1976
Fink, Edwin, Fritz, Hans, Klauser, R., Kupfer, S., Peeters, H., Tschesche, Harald   +5 more
core  

Isolation and Properties of Complexes of the Bowman-Birk Soybean Inhibitor with Trypsin and Chymotrypsin

, 1972
Dinah S. Seidl, Irvin E. Liener
openalex   +1 more source