Results 41 to 50 of about 267,223 (312)

In-vitro effects of biochemical factors on trypsin activity from intestine and pyloric caeca of common kilka (Clupeonella cultriventris caspia) for inhibition of belly bursting [PDF]

, 2012
The in-vitro effects of biochemical factors on trypsin activity from intestine and pyloric caeca of common kilka (Clupeonella cultriventris caspia) was evaluated. Trypsin is known to cause belly bursting in common kilka.
Madani, R., Rezaei, M., Zamani, A.
core  

Fluorescence-based proteasome activity profiling [PDF]

, 2012
With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R., Jong, A., Ovaa, H., Rodenko, B., Schuurman, K.G.   +4 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Streptomyces lavendulae Protease Inhibitor: Purification, Gene Overexpression, and 3-Dimensional Structure

Journal of Chemistry, 2015
Protease inhibitors trypsin (STI1, Streptomyces trypsin inhibitor 1) has been identified, purified by ammonium sulfate precipitation and Sephadex G-100 gel filtration. SDS-PAGE of protease inhibitor showed molecular weight of approximately 10 KDa.
D. E. El-Hadedy, El-Sayed E. Mostafa, Moataza M. Saad   +2 more
doaj   +1 more source

A new family of diverse skin peptides from the microhylid frog genus phrynomantis [PDF]

, 2020
A wide range of frogs produce skin poisons composed of bioactive peptides for defence against pathogens, parasites and predators. While several frog families have been thoroughly screened for skin-secreted peptides, others, like the Microhylidae, have ...
Ballet, Steven, Martel, An, Martin, Charlotte, Pasmans, Frank, Raaymakers, Constantijn, Roelants, Kim, Stijlemans, Benoit, Zaman, Shabnam   +7 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Partial purification of trypsin inhibitors from Parkia seeds (Fabaceae)

Hoehnea, 2014
Leguminous seeds (Fabaceae) have a high content of inhibitors of which serine protease inhibitors are the most widely studied. However, there are only a few studies related to the investigation of these proteins in tree species belonging to the Amazon ...
Larissa Ramos Chevreuil, José Francisco de Carvalho Gonçalves, Leonardo de Azevedo Calderon, Luiz Augusto Gomes de Souza, Silvana Cristina Pando, Eduardo Euclydes de Lima e Borges   +5 more
doaj  

Cinética de inativação de inibidores de tripsina e de insolubilização de proteínas de diferentes cultivares de soja Inactivation kinetics of low activity trypsin inhibitors and protein insolubilization of different soybean cultivars

Revista Brasileira de Zootecnia, 2005
A soja (Glycine max (L.) Merrill) é uma das leguminosas mais estudadas, em virtude de sua intensa utilização como fonte de óleo comestível e proteína para alimentação humana e animal.
Edna Mayumi Yuahasi Miura, Rui Sérgio dos Santos Ferreira da Silva, Ivone Yurika Mizubuti, Elza Iouko Ida   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

In-vitro effects of biochemical factors on trypsin activity from intestine and pyloric caeca of common kilka (Clupeonella cultriventris caspia) for inhibition of belly bursting

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2011
The in-vitro effects of biochemical factors on trypsin activity from intestine and pyloric caeca of common kilka (Clupeonella cultriventris caspia) was evaluated. Trypsin is known to cause belly bursting in common kilka.
A. Zamani; M. Rezaei email ; R. Madani
doaj