Results 151 to 160 of about 14,721 (198)

Tryptase inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2017
Tryptase is one of the main serine-proteinases located in the secretory granules of mast cells, and is released through degranulation, which is involved in the pathogenesis of allergic inflammatory disease, cardiovascular diseases, lung fibrosis and tumor.
Wei-Wei, Ni, Meng-Da, Cao, Wen, Huang, Ling, Meng, Ji-Fu, Wei   +4 more
openaire   +2 more sources

Serum Concentrations of Tryptase in Children

Pediatric Allergy, Immunology, and Pulmonology, 2014
Background: Mast cells are dispersed in many tissues, especially in digestive and respiratory-tract mucosal membranes. Tryptase, considered a marker of mast-cell activity, is the most important protease released from these cells during degranulation.
Katarzyna, Sznurkowska, Katarzyna, Plata-Nazar, Grażyna, Sikorska-Wiśniewska, Ilona, Gruszczyńska, Joanna, Renke, Marek, Niedoszytko, Jolanta, Gleń, Barbara, Kamińska   +7 more
openaire   +2 more sources

A Role for Tryptase in the Activation of Human Mast Cells: Modulation of Histamine Release by Tryptase and Inhibitors of Tryptase

The Journal of Pharmacology and Experimental Therapeutics, 1998
Tryptase, the most abundant protein product of human mast cells is emerging as an important mediator and target for therapeutic intervention in allergic disease. We have investigated the potential of tryptase and inhibitors of tryptase to modulate histamine release from human mast cells.
S, He, M D, Gaça, A F, Walls
openaire   +2 more sources

Die Co-Tryptase (Enterokinase)

1927
Der spezifische Aktivator der Tryptase, die Enterokinase oder, wie man ihn in Analogie mit den ubrigen Co-Enzymen nennen sollte, die Co-Tryptase, ist nunmehr, besonders durch die Untersuchungen von Waldschmidt-Leitz gut bekannt geworden. Im folgenden wird auf Grund der Arbeiten dieses Forschers uber die wichtigsten Ergebnisse berichtet.
Hans v. Euler, Karl Myrbäck
openaire   +2 more sources

TRYPTASE INHIBITORS

2002
Compounds of formula (I) in which M, B1, B2, R1, R2, R6, R7, K1 and K2 have the meanings indicated in the description are novel active tryptase inhibitors.
ALTANA PHARMA AG, MARTIN THOMAS, ULRICH WOLF-RUEDIGER   +2 more
openaire   +1 more source

Tryptase

1927
Hans v. Euler, Karl Myrbäck
openaire   +2 more sources

Elevated Tryptase: Conditions and Pitfalls

The Journal of Allergy and Clinical Immunology: In Practice, 2022
Thanai, Pongdee, Mariana, Castells
openaire   +2 more sources

Heritable risk for severe anaphylaxis associated with increased α-tryptase–encoding germline copy number at TPSAB1

Journal of Allergy and Clinical Immunology, 2021
Jonathan J Lyons, Jack Chovanec, Roberta Zanotti   +2 more
exaly  

Tryptase

1998
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis

Journal of Allergy and Clinical Immunology, 2022
Jack Chovanec, Lawrence B Schwartz, Sarah C Glover   +2 more
exaly