Results 181 to 190 of about 21,184 (241)
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Expression of α-tryptase and β-tryptase by human basophils
Journal of Allergy and Clinical Immunology, 2004Background α and β-Tryptase levels in serum are clinical tools for the evaluation of systemic anaphylaxis and systemic mastocytosis. Basophils and mast cells are known to produce these proteins. Objective The current study examines the effect of the α,β-tryptase genotype on basophil tryptase levels and the type of tryptase stored in these cells ...
Lawrence Schwartz +2 more
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma [PDF]
Cell, 2019 Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and represent an unmet need. We show that mast cell tryptase is elevated in severe asthma patients independent of type 2 biomarker ...
Benjamin T Walters +2 more
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The Journal of Pharmacology and Experimental Therapeutics, 1998
Tryptase, the most abundant protein product of human mast cells is emerging as an important mediator and target for therapeutic intervention in allergic disease. We have investigated the potential of tryptase and inhibitors of tryptase to modulate histamine release from human mast cells.
S, He, M D, Gaça, A F, Walls
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Tryptase, the most abundant protein product of human mast cells is emerging as an important mediator and target for therapeutic intervention in allergic disease. We have investigated the potential of tryptase and inhibitors of tryptase to modulate histamine release from human mast cells.
S, He, M D, Gaça, A F, Walls
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Expression of alpha-tryptase and beta-tryptase by human basophils.
The Journal of allergy and clinical immunology, 2004Alpha and beta-tryptase levels in serum are clinical tools for the evaluation of systemic anaphylaxis and systemic mastocytosis. Basophils and mast cells are known to produce these proteins.The current study examines the effect of the alpha,beta-tryptase genotype on basophil tryptase levels and the type of tryptase stored in these cells.Tryptase ...
Sherryline, Jogie-Brahim +4 more
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BOVINE TRYPTASE: PURIFICATION AND CHARACTERIZATION
Biological Chemistry Hoppe-Seyler, 1992Bovine tryptase, a mast cell trypsin-like protease, was isolated from liver capsula and from mast cells obtained from the same tissue. The purification procedure which leads to an increase in tryptase activity of 850 fold, involves high salt extraction, hydrophobic interaction chromatography on octyl-Sepharose and affinity chromatography on heparin ...
Fiorucci, L, Erba, F, Ascoli, F
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Post mortem tryptase cut-off level for anaphylactic death
Forensic Science International, 2018 Serum mast cell tryptase is used to support the diagnosis of anaphylaxis. The recommended clinical cut-off for total tryptase (
Rexson Tse, Christopher X Wong
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Serum Concentrations of Tryptase in Children
Pediatric Allergy, Immunology, and Pulmonology, 2014Background: Mast cells are dispersed in many tissues, especially in digestive and respiratory-tract mucosal membranes. Tryptase, considered a marker of mast-cell activity, is the most important protease released from these cells during degranulation.
Katarzyna, Sznurkowska +7 more
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Total tryptase or β-tryptase in post mortem settings: Which is to be preferred?
Forensic Science International, 2018Dear Editor, We have read with attention and interest the Tsea et al. manuscript [1] entitled “Post mortem tryptase cut-off level for anaphylactic death” where a 5-year retrospective study has compared totaltryptase levels in the femoral blood of 9 anaphylactic deaths and 45 controls. A cut-off of 53.8 mg/L was identified for total post mortem tryptase
Zaami S., Busardo F. P.
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