Results 291 to 300 of about 1,400,417 (341)
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Trends in Molecular Medicine, 2013
Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T. +1 more
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Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T. +1 more
openaire +1 more source
Food & Function
Anxiety- and depression-like behaviors are commonly observed clinical features of depression and many other mental disorders. Recent evidence has revealed the crucial role of the microbiota-gut-brain axis in the bidirectional communication between the ...
Longgang Jia +9 more
semanticscholar +1 more source
Anxiety- and depression-like behaviors are commonly observed clinical features of depression and many other mental disorders. Recent evidence has revealed the crucial role of the microbiota-gut-brain axis in the bidirectional communication between the ...
Longgang Jia +9 more
semanticscholar +1 more source
Journal of Agricultural and Food Chemistry, 2021
Fuzhuanbrick tea (FBT) has attracted wide attention because of its substantial nutritional value. This article first studied the protective mechanism of FBT polysaccharide (FBTP) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) by 16S rDNA
W. Yang +4 more
semanticscholar +1 more source
Fuzhuanbrick tea (FBT) has attracted wide attention because of its substantial nutritional value. This article first studied the protective mechanism of FBT polysaccharide (FBTP) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) by 16S rDNA
W. Yang +4 more
semanticscholar +1 more source
Tryptophan Metabolism in Phenylketonurics
JAMA, 1961ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown. Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain ...
F A, REICHLE +3 more
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Journal of Agricultural and Food Chemistry
The balance of gut microbiota affects uric acid synthesis and excretion, influencing the development of hyperuricemia. This study aimed to investigate the effects and mechanisms of probiotics on hyperuricemia and adenine- and potassium oxonate-induced ...
Qianxu Wang +9 more
semanticscholar +1 more source
The balance of gut microbiota affects uric acid synthesis and excretion, influencing the development of hyperuricemia. This study aimed to investigate the effects and mechanisms of probiotics on hyperuricemia and adenine- and potassium oxonate-induced ...
Qianxu Wang +9 more
semanticscholar +1 more source
Phytotherapy Research, 2022
Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota. Depressive behaviors in mice induced using chronic unpredictable mild stress (CUMS) stimulation were evaluated by behavioral experiments.
Pingyuan Ge +9 more
semanticscholar +1 more source
Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota. Depressive behaviors in mice induced using chronic unpredictable mild stress (CUMS) stimulation were evaluated by behavioral experiments.
Pingyuan Ge +9 more
semanticscholar +1 more source
Free Tryptophan in Plasma and Brain Tryptophan Metabolism
Nature, 1972SYNTHESIS in the brain of the putative transmitter 5-hydroxytryptamine (5HT) is influenced by the concentration of tryptophan; the rate limiting step in 5HT synthesis is the hydroxylation of tryptophan1 by tryptophan hydroxylase, which is normally unsaturated with substrate2.
P J, Knott, G, Curzon
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Tryptophan and serotonin metabolism after sustained tryptophan infusion
Neurochemistry International, 1984In an attempt to elucidate the effects of sustained administration of tryptophan on serotonin synthesis and turnover in mammalian brain, mini-osmotic pumps containing tryptophan or vehicle were implanted in albino mice for 24 and 96 h. Despite the extremely low dose of tryptophan administered by these pumps (8-12 mg/kg-day) statistically significant ...
Peters, Ralph I., Buhr, Bruce R.
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L-tryptophan metabolism in phenylketonuria
The Journal of Pediatrics, 1966A disturbance of the intestinal transport of L-tryptophan and L-tyrosine secondary to the high blood phenylalanine content has been suggested. The L-tryptophan metabolic abnormalities observed in untreated phenylketonuria appear to be due to a transport defect of this amino acid.
M T, Yarbro, J A, Anderson
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Archives of Dermatology, 1967
A young girl with scleroderma and 21 members of her family were studied for their ability to metabolize tryptophan by the pathway which leads to nicotinic acid. Nine of ten female members of the family and two of 12 males had abnormal tryptophan metabolism.
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A young girl with scleroderma and 21 members of her family were studied for their ability to metabolize tryptophan by the pathway which leads to nicotinic acid. Nine of ten female members of the family and two of 12 males had abnormal tryptophan metabolism.
openaire +1 more source