Results 291 to 300 of about 1,375,182 (353)

Tryptophan Metabolism in Atherosclerosis and Diabetes

Current Medicinal Chemistry, 2022
: The essential amino acid tryptophan (Trp) undergoes catabolism through several pathways, producing biologically active metabolites that significantly impact physiological processes. The metabolic pathway responsible for the majority of Trp catabolism is the kynurenine synthesis pathway (KP).
Sudar-Milovanović, Emina, Gluvić, Zoran, Obradović, Milan M., Zarić, Božidarka, Isenović, Esma R.   +4 more
openaire   +3 more sources

Free Tryptophan in Plasma and Brain Tryptophan Metabolism [PDF]

Nature, 1972
SYNTHESIS in the brain of the putative transmitter 5-hydroxytryptamine (5HT) is influenced by the concentration of tryptophan; the rate limiting step in 5HT synthesis is the hydroxylation of tryptophan1 by tryptophan hydroxylase, which is normally unsaturated with substrate2.
G. Curzon, P. J. Knott
openaire   +2 more sources

Tryptophan Metabolism in Phenylketonurics

JAMA, 1961
ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown. Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain ...
Robert C. Baldridge, June Dobbs, Frederick A. Reichle, Marianne Trompetter   +3 more
openaire   +3 more sources

Tryptophan Metabolism in Rabbits

2003
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway were studied in male New Zealand white rabbits. Activities are expressed both as specific activity and per g of fresh tissue. Liver tryptophan 2,3-dioxygenase activity (TDO), when assayed in either the absence (holoenzyme) or presence of added haematin (apoenzyme), did not
ALLEGRI, GRAZIELLA, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, BIASIOLO M, COSTA, CARLO VIRGILIO LUIGI   +4 more
openaire   +4 more sources

Berberine ameliorates depression‐like behavior in CUMS mice by activating TPH1 and inhibiting IDO1‐associated with tryptophan metabolism

Phytotherapy Research, 2022
Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota. Depressive behaviors in mice induced using chronic unpredictable mild stress (CUMS) stimulation were evaluated by behavioral experiments.
Pingyuan Ge, Shu-Yue Qu, Sai-Jia Ni, Zeng-Ying Yao, Yi-Yu Qi, Xin Zhao, Rui Guo, Nianyun Yang, Qi-Chun Zhang, Huahe Zhu   +9 more
semanticscholar   +1 more source

Neuroprotective effects of probiotics on anxiety- and depression-like disorders in stressed mice by modulating tryptophan metabolism and the gut microbiota.

Food & Function
Anxiety- and depression-like behaviors are commonly observed clinical features of depression and many other mental disorders. Recent evidence has revealed the crucial role of the microbiota-gut-brain axis in the bidirectional communication between the ...
Longgang Jia, Ling Xiao, Yao Fu, Zhen Shao, Zhaoxuan Jing, Jiahu Yuan, Yufeng Xie, Jun Guo, Yanping Wang, Weitao Geng   +9 more
semanticscholar   +1 more source

Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.

Journal of Agricultural and Food Chemistry, 2022
Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day ...
Shanshan Hu, Liyong Luo, X. Bian, R. Liu, Si-jia Zhao, Yu Chen, K. Sun, Jie-ling Jiang, Zhonghua Liu, L. Zeng   +9 more
semanticscholar   +1 more source

Fuzhuan Brick Tea Polysaccharide Improved Ulcerative Colitis in Association with Gut Microbiota-Derived Tryptophan Metabolism.

Journal of Agricultural and Food Chemistry, 2021
Fuzhuanbrick tea (FBT) has attracted wide attention because of its substantial nutritional value. This article first studied the protective mechanism of FBT polysaccharide (FBTP) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) by 16S rDNA
W. Yang, Daoyuan Ren, Yan Zhao, Lei Liu, Xingbin Yang   +4 more
semanticscholar   +1 more source

Tryptophan Metabolism and Sleep

2015
Sleep and sleep medicine are in the limelight of the researchers for thousands of years. The definition of sleep started to change in the light of scientific experiments performed in the twentieth century, and the number of investigations on sleep medicine increased tremendously.
KÖKTÜRK, OĞUZ, KANBAY, ASİYE
openaire   +3 more sources