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Screening for defects in tryptophan metabolism
Journal of Chromatography A, 2000We introduced a two-step procedure for the detection of defects in metabolism of tryptophan: (1) HPTLC (described previously) is suitable when starting the investigation, (2) two HPLC methods with isocratic elution and spectrophotometric detection are used at the next step, when pathological findings are to be confirmed and the individual metabolites ...
I. Krakorova +2 more
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Tryptophan metabolism in depressive illness
Psychological Medicine, 1974SYSNOPSIS[Methylene-14C]-L-tryptophan was administered intravenously to five patients suffering from severe depression before and after clinical recovery, and to six control subjects; all subjects were tested while on a standard diet. [14C]-5-Hydroxyindoleacetic acid and [14C]-indoleacetic acid were isolated from urine during the following 48 hours and
B. W. L. Brooksbank +4 more
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Tryptophan Metabolism in Analbuminemic Rats1
The Journal of Biochemistry, 1983Studies were made on tryptophan metabolism in Nagase analbuminemic rats (NAR), a mutant strain established from Sprague-Dawley rats that is characterized by lack of plasma albumin and hyperlipidemia. The total tryptophan concentration in NAR plasma is one fifth of normal, but the plasma free tryptophan concentration and liver and brain tryptophan ...
Sumi Nagase +2 more
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Tryptophan Metabolism in Affective Psychoses
British Journal of Psychiatry, 1966Tryptophan has attracted attention during recent years for the possible role played by some of its metabolites in the aetiology and treatment of psychiatric disorders. Of these metabolites, serotonin has received special attention and considerable work has been carried out in order to elucidate its physiological and pharmacological actions.
A Mangoni, C L Cazzullo, G Mascherpa
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Diabetes and Tryptophan Metabolism
2015Tryptophan, an essential amino acid, can be metabolized to several kinds of physiologically active metabolites. Accumulating data indicate that an altered metabolism of tryptophan and its active metabolites have important roles for the pathogenesis and development of complications of diabetes mellitus.
Ugur Unluturk, Tomris Erbas
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Tryptophan metabolism in acrodermatitis enteropathica
The Journal of Pediatrics, 1973Tryptophan-loading tests were performed on two normal subjects before and after diiodohydroxyquin treatment and on three acrodermatitis enteropathica patients being treated with diiodohydroxyquin. Patients who received a loading dose of tryptophan had higher urinary levels of kynurenine, kynurenic acid, and acetylkynurenine in comparison with normal ...
Alex F. Robertson +3 more
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Metabolism of Tryptophan in Depressive Disease
Archives of General Psychiatry, 1973The metabolism of tryptophan (TRYP) to kynurenine and its metabolites, to tryptamine, and through serotonin to 5-hydroxyindoleacetic acid was studied in nine depressed patients and six non-depressed psychiatric subjects. In general, there were no significant differences in the basal urinary excretion of the nine metabolites measured between the two ...
Ghanshyam N. Pandey +2 more
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Tryptophan metabolism in experimental porphyria
Biochemical Pharmacology, 1967Abstract Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l -tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l -kynurenine and 3-OH-kynurenine.
Moisés Grinstein, Augusto F. Garcia
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Metabolism and Biology of Tryptophan
1996The age of 21 years is usually considered the age at which a person becomes an adult. So it is that the International Study Group for Tryptophan Research (ISTRY), which is now 21 years old becomes a mature organization. The first meeting was held 21 years ago here in beautiful and historic Padua organized by Professor L.
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TRYPTOPHAN METABOLISM IN CARCINOMA OF THE BREAST
The Lancet, 1967Abstract The excretions of three tryptophan metabolites, 3-hydroxykynurenine, xanthurenic acid, and 3-hydroxyanthranilic acid, have been determined in the urine of 15 controls, 20 patients treated for cancer of the breast by mastectomy alone, and 24 patients treated by oophorectomy and mastectomy.
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