Results 151 to 160 of about 18,686 (194)
miR-495-3p inhibition rescues mTORC1 hyperactivation-driven autistic-like behaviors in mice
Levone BR +4 more
europepmc +1 more source
TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop
Lamprakis A, Demetriades C.
europepmc +1 more source
Tsc1 regulates tight junction independent of mTORC1 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The epithelium barrier is vital for sealing body surface and alimentary spaces, preventing paracellular material diffusion and pathogen invasion. We describe here that tuberous sclerosis complex 1 (Tsc1) controls tight junction (TJ) formation to create and maintain the epithelial barrier, independent of its conventional ...
Li Liang, Sheng Zhang, Xiaochun Bai
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Role of TSC1 in physiology and diseases
Molecular and Cellular Biochemistry, 2021Since its initial discovery as the gene altered in Tuberous Sclerosis Complex (TSC), an autosomal dominant disorder, the interest in TSC1 (Tuberous Sclerosis Complex 1) has steadily risen. TSC1, an essential component of the pro-survival PI3K/AKT/MTOR signaling pathway, plays an important role in processes like development, cell growth and ...
Karthik Mallela, Arun Kumar
openaire +2 more sources
Structure of the TBC1D7-TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region. [PDF]
Journal of Molecular Cell Biology, 2016 TSC1 and TSC2 mutations account for the majority of tuberous sclerosis complex cases. The TSC1 and TSC2 proteins assemble into a complex that is stabilized by TBC1D7 through its direct interaction with the TSC1 coiled coil (CC) region. Loss of TBC1D7 is associated with intellectual disability and megalencephaly. Here, we determine the crystal structure
Mark Nellist, Zhongchao Gai
exaly +4 more sources
Analysis of TSC1 mutation spectrum in mucosal melanoma
Journal of Cancer Research and Clinical Oncology, 2017Mucosal melanoma is a relatively rare subtype of melanoma for which no clearly established therapeutic strategy exists. The genes of the mTOR signalling pathway have drawn great attention as key targets for cancer treatment, including melanoma. In this study, we aimed to investigate the mutation status of the upstream mTOR regulator TSC1 and evaluated ...
Huan Yu, Jie Dai, Jun Guo
exaly +3 more sources
Evolution of the TSC1/TSC2-TOR Signaling Pathway
Science Signaling, 2010The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth.
Jaco, Serfontein +3 more
openaire +2 more sources
Tsc1 controls the development and function of alveolar macrophages
Biochemical and Biophysical Research Communications, 2018Alveolar macrophages (AMs) are pivotal for maintaining the lung homeostasis, but how the development and function of AMs regulated remains largely unknown. In the present study, we demonstrated that the number of AMs was controlled by the Tsc1 protein. Cd11c-specific deletion of Tsc1 caused inefficient transition from pre-AMs to AMs in lung, which led ...
Song, Chen +5 more
openaire +2 more sources