Results 141 to 150 of about 20,458 (226)

Isolation and characterization of the TSC1 gene promoter

, 2002
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with loci on chromosome 9q34 (TSC1) and chromosome 16p13.3 (TSC2). Genes for both loci have been isolated and characterized. During the present study, we have used the PCR methodology to isolate approximately 1.6 kb of the genomic sequence, 5' to the published TSC1 cDNA.
Ali, Mahmood, Girimaji, SC, Kumar, Arun
openaire   +1 more source

破骨细胞条件性Tsc1敲除小鼠模型构建

Zhongguo shiyan zhenduanxue
目的基于Cre-loxp重组酶系统，构建破骨细胞特异性Tsc1基因条件性敲除（cKO）小鼠模型，为深入研究Tsc1基因在骨质疏松症及其他骨代谢性疾病中的分子机制提供可靠的实验动物模型。方法将CtskCre/+小鼠与Tsc1flox/flox小鼠进行交配与筛选，获得实验组（CtskCre/+/Tsc1flox/flox）及其同窝对照的野生型小鼠。采用碱裂解法提取小鼠基因组DNA，并通过PCR扩增及琼脂糖凝胶电泳进行基因型鉴定。提取总蛋白后采用Western blot技术在蛋白水平检测TSC1蛋白的表达情况。
张晟, 廖正权, 吴俊锋, 王岩, 王红   +4 more
doaj  

Region- and Compartment-Specific Elevation of Bone Mass in Mice Following Tsc1 Deletion in 8-kb Dmp1-Cre-Expressing Cells. [PDF]

Calcif Tissue Int
Ghassib I, Inti A, Hossain N, Kim T, Moon D, Han L, Mohsen R, Zhang H, Auyeung N, Mishina Y, Mendonça D, Kaigler D, Bellido T, Liu F.   +13 more
europepmc   +1 more source

Genotypic and phenotypic features of 23 Egyptian patients with tuberous sclerosis complex. [PDF]

BMC Pediatr
Othman AA, Sadek AA, Aladawy MA, Aziz SP, Sedky A, Mansour TMM, Younis MMS, Abdelatif RG, Hassan AEM, Aboelmagd MA, Mohamed M, Mohamed KR, Elkousy SM, Montaser Elkady NM, Khang R, Ryu SW, Abdelkreem E.   +16 more
europepmc   +1 more source

GSK-J4 Suppresses Tumorigenesis by Targeting the PERK-c-Myc Pathway Through Endoplasmic Reticulum Stress Activation in Tuberous Sclerosis Complex. [PDF]

Int J Mol Sci
Lei X, Lang T, Li P, Wu C.
europepmc   +1 more source

Clinical characteristics and molecular genetic analysis of 73 cases of tuberous sclerosis complex caused by <i>TSC1/2</i> gene mutations in children. [PDF]

Front Pediatr
Wu X, He MY, Xu HF, He Y, Min XH, Zhao QK, Liang SQ, Ginowree NBN, Hu SH, Yin J, Fan ZH, Din MJU, Zhu M, Zhang G.   +13 more
europepmc   +1 more source

Evidence for FOXL2 Association with the Tsc1 Regulatory Region in Mice. [PDF]

Biomolecules
Marongiu M, Marcia L, Sbardellati A, Deiana M, Asunis I, Pelosi E, Coschiera A, Crobu F, Loi A, Melis E, Mostallino MC, Meloni A, Cusano R, Cucca F, Uda M, Crisponi L.   +15 more
europepmc   +1 more source

The influence of resveratrol treatment in combination with tsc1 knock out on the mammalian cell growth

, 2007
Cell growth and cell proliferation are two very important processes for multicellular organisms. In mammalian systems these processes are coordinated by a protein-complex mTOR, which is a central regulator of a complex signaling transduction pathway ...
Yang, Weishan, Wang, Huiyun, Haugaard, Anastasiya, Fan, Yuzhou, Cong, Zhiyuan   +4 more
core  

Interpretable EEG biomarkers for neurological disease models in mice using bag-of-waves classifiers. [PDF]

J Neural Eng
Isabel Cano Achuri M, Kay Lara M, Abed Rabbo K, Wilson BT, Meek A, Mahoney JM, Hernan AE, Brockmeier AJ.   +7 more
europepmc   +1 more source

Intact mTOR signaling in gastric X/A-like cells is required for bone homeostasis. [PDF]

Front Endocrinol (Lausanne)
Feng T, Yin W, Picoli CC, Liu L, Le PT, Liu Z, Yu R, Eltahir M, Zohori R, Rosen CJ, Zhang W, Li Z.   +11 more
europepmc   +1 more source