Results 121 to 130 of about 20,458 (226)
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi +4 more
wiley +1 more source
TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
, 2015 SummaryThe tuberous sclerosis proteins TSC1 and TSC2 are key integrators of growth factor signaling. They suppress cell growth and proliferation by acting in a heteromeric complex to inhibit the mammalian target of rapamycin complex 1 (mTORC1).
Baumeister, Ralf +38 more
core +1 more source
TSC2 Modulates Actin Cytoskeleton and Focal Adhesion Through TSC1-Binding Domain and the Rac1 GTPase
, 2004 Tuberous sclerosis complex (TSC) 1 and TSC2 are thought to be involved in protein translational regulation and cell growth, and loss of their function is a cause of TSC and lymphangioleiomyomatosis (LAM).
Goncharov, Dmitry +7 more
core +1 more source
Loss of FoxO function leads to enhancement of Tsc1 overgrowth under NR.
, 2018 (A) Eyes bearing eyFlp control, Tsc1 or PTEN mutant clones (marked by the absence of pigmentation), with or without FoxO mutation of animals reared on normal food or NR. Removal of FoxO caused lethality of Tsc1 mutant animals under NR. (B) Eye discs with
Hugo Stocker (2648) +2 more
core +1 more source
Effect of TBC1D7 amino acid substitutions on the TSC1-TSC2-TBC1D7 complex.
, 2014 To assess the effects of the TBC1D7 variants on the TSC1-TSC2-TBC1D7 interaction, the TBC1D7 variants were coexpressed with TSC1 and TSC2 in transfected HEK 293T cells. A.
Marianne Hoogeveen-Westerveld (549062) +7 more
core +1 more source
Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
, 2019 Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in TSC1 or TSC2, which encode proteins that negatively regulate mTOR complex 1 (mTORC1).
Ahmed, Kamran M +8 more
core +1 more source
Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate
Stem Cell Research & TherapyBackground Tuberous sclerosis complex is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, affecting multiple systems. These genes produce proteins that regulate mTORC1 activity, essential for cell function and metabolism.
Shuang Wang +7 more
doaj +1 more source
Scientific ReportsTuberous Sclerosis Complex (TSC) is an autosomal dominant disorder characterized by widespread hamartomas and prominent neurological involvement. It results from pathogenic variants in the TSC1 or TSC2 genes, leading to hyperactivation of the mTOR ...
Andrea Domenico Praticò +13 more
doaj +1 more source
Pediatric Investigation, Volume 10, Issue 3, Page 284-287, June 2026.
Haoxuan Li +6 more
wiley +1 more source
Tsc1+andtsc2+Regulate Arginine Uptake and Metabolism inSchizosaccharomyces pombe
, 2004 Mutations in either TSC1 or TSC2 cause tuberous sclerosis complex, an autosomal dominant disorder characterized by seizures, mental retardation, and benign tumors of the skin, brain, heart, and kidneys.
Warren D. Kruger +9 more
core +1 more source