Results 111 to 120 of about 20,458 (226)

Assessment of the effects of the TSC1 Y948N, I954K and L963S variants on TORC1 signaling.

, 2014
The TSC1 variants were coexpressed in transfected HEK 293T cells with TSC2 and S6K. TSC2, TSC1, S6K and T389-phosphorylated S6K (T389) signals were estimated by immunoblotting.
Marianne Hoogeveen-Westerveld (549062), Ans van den Ouweland (89937), Ushio Kikkawa (226238), Anneke Maat-Kievit (549063), Dicky Halley (366558), Mark Nellist (549064), Arthur Jorge Santiago Lima (549061), Akio Nakashima (271973)   +7 more
core   +1 more source

Flies lacking Akt phosphorylation sites on Tsc1 and Tsc2 are viable and normal in size.

, 2013
(A) Expression levels of myc-Tsc1 in fly lines homozygous for the Tsc129 mutation, rescued by ubiquitous expression of Tsc1WT, Tsc1S533A or Tsc1S533D, or flies homozygous for both the Tsc129 and Tsc2192 mutations rescued to viability by ubiquitous ...
Aurelio A. Teleman (187510), Sibylle Schleich (371798)   +1 more
core   +1 more source

Enterococcus faecalis Extracellular Vesicles Deliver the Bacterial GTPase Obg to Hijack mTOR Signalling in Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma, Xiaoshan Xie, Jiarui Wang, Zhikai Zheng, Huilin Jin, Xijie Chen, Xiaoling Huang, Haidan Luo, Yue Wei, Qihao Pan, Boyu Zhang, Jiaying Zheng, Peng Zhang, Fenghai Yu, Xue Liu, Zhi‐Min Zhang, Zhongguo Zhou, Xiangqi Meng, Mong‐Hong Lee   +18 more
wiley   +1 more source

From 2D to 3D Bioprinted In Vitro Breast Cancer Model: A Comparative Study of Proliferation, Tissue Structure, and mTOR Signaling

MedComm, Volume 7, Issue 6, June 2026.
A 3D bioprinted breast cancer model was created to more accurately reproduce in vivo tumor characteristics compared to conventional 2D cultures. Distinct cell adhesion patterns, reduced mTOR signaling, and altered drug responses were observed under 3D conditions.
Dorottya Moldvai, Gábor Petővári, Rebeka Gelencsér, Dániel Sztankovics, Risa Miyaura, Viktória Varga, Fatime Szalai, Kornélia Baghy, Ildikó Krencz, Titanilla Dankó, Anna Sebestyén   +10 more
wiley   +1 more source

Flies lacking Akt phosphorylation sites on both Tsc1 and Tsc2 are slightly lean.

, 2013
Triglyceride levels normalized to total body protein for Tsc129 homozygotes rescued by ubiquitous expression of Tsc1WT (“WT”), Tsc1S533A (“S533A”) or Tsc1S533D(“S533D”), or flies homozygous for both the Tsc129 and Tsc2192 mutations rescued to viability ...
Aurelio A. Teleman (187510), Sibylle Schleich (371798)   +1 more
core   +1 more source

The role of TSC1 and TSC2 proteins in neuronal axons

Molecular Psychiatry
Tuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the proper development and function of the nervous system. This complex primarily acts as an inhibitor of the mechanistic target of rapamycin (mTOR) kinase, and mutations in either TSC1 or TSC2 cause a ...
Vasiliki Karalis, Delaney Wood, Nicole A. Teaney, Mustafa Sahin   +3 more
openaire   +2 more sources

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex

, 2012
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 genes. The TSC1 and TSC2 gene products, TSC1 and TSC2, form a complex that inhibits the mammalian target of rapamycin (mTOR) complex 1 (TORC1 ...
Ekong, Rosemary, Povey, S, Mayer, K., Sparagana, Steven P., Sparagana, S.P., Hoogeveen-Westerveld, M., Thiele, Elizabeth, Aalfs, Cora, Thompson, C, Ans van den Ouweland, Elizabeth Thiele, Agnies van Eeghen, Cora Aalfs, Karbassi, I, Thiele, E., Nellist, M., Catherine Thompson, Thompson, Catherine, Dies, Kira, Ekong, R., Dunnen, JT, Wen, L., Karin Mayer, Ekong, R, Wen, L, Aalfs, C, Batish, Sat Dev, Johan T. den Dunnen, Nellist, Mark, Eeghen, A. van, van den Ouweland, Ans, Izabela Karbassi, Li Wen, Dicky Halley, van Eeghen, Agnies, Halley, Dicky, Steven P. Sparagana, den Dunnen, Johan T., Dies, K., Rosemary Ekong, Sue Povey, Hoogeveen - Westerveld, Marianne, Mark Nellist, Mayer, K, Povey, Sue, Davies, P, Karbassi, I., Peter Davies, Thiele, E, Povey, S., Sparagana, SP, Halley, D., Davies, Peter, Sat Dev Batish, Wen, Li, Karbassi, Izabela, Kira Dies, Batish, SD, Aalfs, C., Marianne Hoogeveen-Westerveld, Dunnen, J.T. den, Mayer, Karin, Ouweland, A. van den, Batish, S.D., Thompson, C., Hoogeveen-Westerveld, Marianne, Davies, P., Dies, K   +67 more
core   +1 more source

Identification of a complex intrachromosomal inverted insertion in the long arm of chromosome 9 as a cause of tuberous sclerosis complex in a Korean family

Molecular Genetics & Genomic Medicine
Background Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder, caused by a loss‐of‐function of either TSC1 or TSC2 gene. However, in 10%–15% TSC patients there is no pathogenic variant identified in either TSC1 or TSC2 genes ...
Seung Woo Ryu, Ji‐Hee Yoon, Dong‐wook Kim, Beomman Han, Heonjong Han, Joohyun Han, Hane Lee, Go Hun Seo, Beom Hee Lee   +8 more
doaj   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source