Results 91 to 100 of about 20,458 (226)
Frontiers in Neurology, 2020 Tuberous sclerosis complex (TSC) is a genetic disease characterized by seizures, mental deficiency, and abnormalities of the skin, brain, kidney, heart, and lungs. TSC is inherited in an autosomal dominant manner and is caused by variations in either the
Yi-Dan Liu +13 more
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Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley +1 more source
Tsc1 and Tsc2 gene products in neurodegenerative processes
, 2016 O complexo da esclerose tuberosa (TSC) é uma doença genética que pode afetar órgãos específicos de qualquer sistema do organismo humano. Em geral, as lesões surgem pela inativação bialélica de um dos genes supressores tumorais Tuberous Sclerosis Complex ...
Azzi-Nogueira, Deborah
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IJU Case Reports, Volume 9, Issue 4, July 2026.ABSTRACT Introduction Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges. Half of these cases harbor TSC1/TSC2 alterations, and a small subset features TFE3 rearrangements, mutually exclusive of TSC mutations.
Yuka Kondo +8 more
wiley +1 more source
, 2016 Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by mutations of either TSC1 or TSC2 gene with the consequent activation of the mTORC1. This results in the loss of control on cell proliferation and differentiation leading
Dolcetta, D +7 more
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Cancer Cell International, 2020 Background Multiple myeloma (MM) is a prevalent hematological malignancy. Long noncoding RNAs are correlated with the development of MM. In this project, the function of lncRNA opa interacting protein 5-antisense 1 (OIP5-AS1) in MM and the potential ...
Yong Wang +5 more
doaj +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Jingyi Xie +14 more
wiley +1 more source
Rapamycin reverses phenotypes in ΔTsc1 mice.
, 2015 (A) Immunohistochemical staining of phosphorylation of S6 (Ser235/236) in sections of distal femur from 10-week-old control, ΔTsc1 and rapamycin treated ΔTsc1 mice.
Song Xu (187853) +14 more
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Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
Advanced Science, Volume 13, Issue 31, 4 June 2026.This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh +11 more
wiley +1 more source
Drosophila Tsc1 is phosphorylated by Akt on Ser533.
, 2013 (A) Phosphorylation of Tsc1 increases with insulin treatment. S2 cells transfected with constructs to express myc-Tsc1 and His-Tsc2 were treated without insulin (0 min) or with insulin (10 µg/mL) for indicated times (20, 40 or 60 min).
Aurelio A. Teleman (187510) +1 more
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