Results 71 to 80 of about 20,458 (226)

Differential Expression of MicroRNA-19b Promotes Proliferation of Cancer Stem Cells by Regulating the TSC1/mTOR Signaling Pathway in Multiple Myeloma

Cellular Physiology and Biochemistry, 2018
Background/Aims: MiR-19b has been reported to be involved in several malignancies, but its role in multiple myeloma (MM) is still unknown. The objective of this study was to explore the biological mechanism of miR-19b in the progression of MM.
Ni Wang, Xiaohua Liang, Weijian Yu, Shihang Zhou, Meiyun  Fang   +4 more
doaj   +1 more source

Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

Human Genomics, 2023
Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder.
Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda   +8 more
doaj   +1 more source

Retraction: Drosophila yakuba – Tsc1

, 2021
Lose, B; Myers, A; Fondse, S; Alberts, I; Stamm, J; Youngblom, JJ; Rele, CP; Reed, LK (2021). Private: Drosophila yakuba – Tsc1. microPublication Biology. 10.17912/micropub.biology.000407, was mistakenly published before peer-review was completed. This was not an intentional . The published version of the article was made removed from public viewing on
openaire   +1 more source

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

Generation of the T cell-specific Tsc1 KO mice.

, 2012
(A) Western blot analysis showed TSC1 was expressed in thymus, spleen as well as pLNs of WT B6 mice, brain serves as the positive control. (B) Tsc1 and Tsc2 expression level in splenic CD8+T cells was higher than that in B cells and CD4+T cells as ...
Yong Zhao (84950), Hongran Li (181991), Guangwei Liu (181992), Hongbing Zhang (181976), Lanlan Li (181980), Zhuang Miao (181987), Lina Sun (158687), Enyu Rao (181984), Hui Chen (28597), Lianjun Zhang (181973), Yi Xiao (135101)   +10 more
core   +1 more source

Stochastic Model of Tsc1 Lesions in Mouse Brain

PLoS ONE, 2013
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder due to mutations in either TSC1 or TSC2 that affects many organs with hamartomas and tumors. TSC-associated brain lesions include subependymal nodules, subependymal giant cell astrocytomas and tubers.
Shilpa, Prabhakar, June, Goto, Xuan, Zhang, Xuan, Zuang, Miguel, Sena-Esteves, Roderick, Bronson, Jillian, Brockmann, Davide, Gianni, Gregory R, Wojtkiewicz, John W, Chen, Anat, Stemmer-Rachamimov, David J, Kwiatkowski, Xandra O, Breakefield   +12 more
openaire   +6 more sources

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Hepatocyte-specific deletion of Tsc1 leads to mild insulin resistance.

, 2013
A. Liver-specific ablation of Tsc1. Tsc1fl/fl mice were crossed to CreAlb mice resulting in Tsc1fl/fl; Cre+/+ (a.k.a. Tsc1+/+) and Tsc1fl/fl; CreAlb (a.k.a. Tsc1−/−) littermates.
Heidi L. Kenerson (354075), Matthew M. Yeh (354077), Raymond S. Yeung (354078)   +2 more
core   +1 more source

Correlation between TSC1 gene polymorphism and epilepsy

Experimental and Therapeutic Medicine, 2017
The correlation between tuberous sclerosis complex 1 (TSC1) gene polymorphism and epilepsy was studied. In total, 38 patients with epilepsy treated in People's Hospital of Rizhao from May 2015 to June 2016 were selected as study subjects, as the observation group, 38 healthy people in the same period were selected as the control group. Polymerase chain
Jiang, Xiuli, Chen, Jiajia, Song, Quanjiang, Wang, Weiling, Zhang, Guangyan, Li, Ye   +5 more
openaire   +3 more sources

Prenatal diagnosis of cardiac rhabdomyoma: implications for predicting tuberous sclerosis complex and guiding perinatal management

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To identify prenatal predictors of tuberous sclerosis complex (TSC) in fetuses with one or more cardiac rhabdomyomas (CR), evaluate an integrated multimodal diagnostic workflow using fetal magnetic resonance imaging (MRI) and trio whole‐exome sequencing (trio‐WES) and characterize perinatal outcomes.
X. Cai, J. Liu, W. Zheng, Y. Jiao, Y. Lou, M. Deng, W. Zhao, K. Yan, L. Sun   +8 more
wiley   +1 more source