Results 81 to 90 of about 20,458 (226)

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, EarlyView.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

TSC1 amino acids 939 – 977 are sufficient for binding TBC1D7.

, 2014
HA-TBC1D7 was expressed in transfected HEK 293T cells. Glutathione-S-transferase (GST) TSC1 fusion proteins were expressed in E. coli and purified on glutathione-agarose beads.
Marianne Hoogeveen-Westerveld (549062), Ans van den Ouweland (89937), Ushio Kikkawa (226238), Anneke Maat-Kievit (549063), Dicky Halley (366558), Mark Nellist (549064), Arthur Jorge Santiago Lima (549061), Akio Nakashima (271973)   +7 more
core   +1 more source

Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway

Cell Death and Disease
Tuberous sclerosis complex 1 (TSC1) plays important roles in regulating innate immunity. However, the precise role of TSC1 in macrophages in the regulation of oxidative stress response and hepatic inflammation in liver ischemia/reperfusion injury (I/R ...
Ming Ni, Jiannan Qiu, Guoqing liu, Xiaohu Sun, Wenjie Zhu, Peng Wu, Zheng Chen, Jiajing Qiu, Ziming Wu, Yang Zhang, Feng Zhang, Changyong Li, Yuan Gao, Jun Zhou, Qiang Zhu   +14 more
doaj   +1 more source

Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.

Frontiers in Molecular Neuroscience, 2014
The Pten and Tsc1 genes both encode proteins that repress mechanistic target of rapamycin (mTOR) signaling. Disruption of either gene in the brain results in epilepsy and autism-like symptoms in humans and mouse models, therefore it is important to ...
Matthew C Weston, Hongmei eChen, John W Swann   +2 more
doaj   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

TSC1 inhibits cell migration.

, 2013
(A) TSC1-deficient and TSC1-expressing cells were seeded and grown to 100% confluence. The cell monolayer was scratched with a sterile pipette tip. The wounded cultures were photographed after 14 and 43 hours.
Takashi Igarashi (276289), Okio Hino (138949), Masashi Mizuguchi (276290), Maki Ohsawa (276286), Toshiyuki Kobayashi (276287), Hidehiro Okura (276288)   +5 more
core   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

ANRIL regulates retinoblastoma progression via targeting autophagy by miR-328-3p/TSC1/ULK signaling

Retinoblastoma is the most common primary intraocular malignancy of childhood. The aim of our study was to investigate the role and regulatory mechanism of the long non-coding RNA ANRIL in retinoblastoma.
Xiaolong Yin, Yuezhi Zhang, Yang Yang, Yanmei Fu, Shuanglian Li   +4 more
core   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Generation of Tsc1^cko mutant mice and characterization of Tsc1 disruption by western blot and PCR analysis.

, 2013
(A) Schematic representation of deletion of Tsc1 exon17 and exon18 by cyp19-cre mediated recombination in granulosa cells. (B) Granulosa cells were collected from COC of both Tsc1flox/flox mice and Tsc1cko mutant mice and lysed for western blot: Tsc1 was
Zong-Zhe Jiang (288601), Qing-Hua Zhang (160455), Yi-Bo Luo (159570), Yong Zhao (84950), Fei Lin (156666), Zhen-Bo Wang (216040), Heide Schatten (148631), Qing-Yuan Sun (148635), Lin Huang (288599), Meng-Wen Hu (288602), Yi Hou (148620), Heng-Yu Fan (288603)   +11 more
core   +1 more source