Results 11 to 20 of about 29,860 (247)

Tsc1 is a Critical Regulator of Macrophage Survival and Function [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: Tuberous sclerosis complex 1 (Tsc1) has been shown to regulate M1/M2 polarization of macrophages, but the precise roles of Tsc1 in the function and stability of macrophages are not fully understood. Here we show that Tsc1 is required for
Chunmin Fang, Juan Yu, Yuechen Luo, Song Chen, Weiqiang Wang, Chunxiao Zhao, Zhina Sun, Wantong Wu, Wei Guo, Zhongchao Han, Xiao Hu, Fang Liao, Xiaoming Feng   +12 more
doaj   +4 more sources

The Role of TSC1 in the Macrophages Against Vibrio vulnificus Infection [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Vibrio vulnificus (V. vulnificus) is an estuarine bacterium that is capable of causing rapidly fatal infection in humans. Proper polarization and bactericidal activity of macrophages play essential roles in defending against invading pathogens.
Xian-Hui Huang, Xian-Hui Huang, Xian-Hui Huang, Yao Ma, Yao Ma, Yao Ma, Han Lou, Na Chen, Na Chen, Ting Zhang, Liu-Ying Wu, Liu-Ying Wu, Yi-Ju Chen, Yi-Ju Chen, Meng-Meng Zheng, Meng-Meng Zheng, Yong-Liang Lou, Yong-Liang Lou, Yong-Liang Lou, Dan-Li Xie, Dan-Li Xie, Dan-Li Xie   +21 more
doaj   +4 more sources

Regulation of T‐cell survival and mitochondrial homeostasis by TSC1 [PDF]

European Journal of Immunology, 2011
AbstractThe mammalian target of rapamycin (mTOR) is a key regulator of cell growth and metabolism. It associates with multiple proteins and forms two distinct signaling complexes, mTORC1 and mTORC2. Accumulating evidence has revealed critical roles for intact mTOR signaling during T‐cell activation and responses to microbial infection.
Thomas O’Brien, Balachandra K. Gorentla, Danli Xie, Sruti Srivatsan, Ian X. McLeod, You‐Wen He, Xiao‐Ping Zhong   +6 more
openalex   +5 more sources

Structure of the TBC1D7–TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region [PDF]

Journal of Molecular Cell Biology, 2016
TSC1 and TSC2 mutations account for the majority of tuberous sclerosis complex cases. The TSC1 and TSC2 proteins assemble into a complex that is stabilized by TBC1D7 through its direct interaction with the TSC1 coiled coil (CC) region. Loss of TBC1D7 is associated with intellectual disability and megalencephaly. Here, we determine the crystal structure
Zhongchao Gai, Wendan Chu, Wei Deng, Wenqi Li, Hua Li, Ailiang He, Mark Nellist, Geng Wu   +7 more
openalex   +6 more sources

Drosophila yakuba – Tsc1

microPublication biology, 2021
Introduction
James J. Youngblom, Chinmay P Rele, Savannah Fondse, Abigail Myers, Laura K. Reed, Joyce Stamm, Ian Alberts, Bailey Lose   +7 more
openaire   +4 more sources

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits [PDF]

BMC Biochemistry, 2012
Abstract Background Mutations to the TSC1 and TSC2 genes cause the disease tuberous sclerosis complex. The TSC1 and TSC2 gene products form a protein complex that integrates multiple metabolic signals to regulate the activity of the target of rapamycin (TOR) complex 1 (TORC1) and thereby control cell growth.
Marianne Hoogeveen-Westerveld, Mark Nellist, Dicky J. J. Halley, Ans M.W. van den Ouweland, Leontine van Unen, André T. Hoogeveen   +5 more
openaire   +2 more sources

Tsc1 regulates tight junction independent of mTORC1 [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance The epithelium barrier is vital for sealing body surface and alimentary spaces, preventing paracellular material diffusion and pathogen invasion. We describe here that tuberous sclerosis complex 1 (Tsc1) controls tight junction (TJ) formation to create and maintain the epithelial barrier, independent of its conventional role in ...
Mingqiang Lai, Wenchong Zou, Zelong Han, Ling Zhou, Zeyou Qiu, Juan Chen, Sheng Zhang, Pinglin Lai, Kai Li, Yue Zhang, Li Liang, Yu Jiang, Zhipeng Zou, Xiaochun Bai   +13 more
openaire   +3 more sources

Loss of TSC1 in secondary angiosarcoma of the breast

Clinical Case Reports, 2023
Key Clinical MessagePost‐radiation angiosarcoma of the breast is a rare complication associated with a poor prognosis. This case reports the first loss of function mutation in TSC1 in breast radiation‐induced angiosarcoma and illustrates the utility of evaluating these markers to identify potential therapeutic targets.AbstractPost‐radiation ...
Lucy Rose, Nicci Owusu‐Brackett, Stephen Moore, Bridget Oppong   +3 more
openaire   +3 more sources

Comprehensive analysis of the circular RNA expression profile and circRNA–miRNA–mRNA network in the goat skin with divergent wool curvature

Animal Research and One Health, EarlyView., 2023
In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su, Zhanqiang Zhao, Zhanfa Liu, Xiaobo Li, Qian Chen, Yabin Pu, Lin Jiang, Xiaohong He, Yuehui Ma, Qianjun Zhao   +9 more
wiley   +1 more source

TSC1/TSC2 signaling in the CNS [PDF]

FEBS Letters, 2011
Over the past several years, the study of a hereditary tumor syndrome, tuberous sclerosis complex (TSC), has shed light on the regulation of cellular proliferation and growth. TSC is an autosomal dominant disorder that is due to inactivating mutations in TSC1 or TSC2 and characterized by benign tumors (hamartomas) involving multiple organ systems.
Mustafa Sahin, Juliette M. Han
openaire   +2 more sources