Effects of ATF2/TSC1 on epilepsy by modulating the microphages polarization of microglia [PDF]
Scientific ReportsEpilepsy (EP) is a chronic nervous system disease characterized by recurrent attacks, and its causes are complicated. Inflammatory reaction mediated by microglia is an important factor in the progression of EP.
Wenjiao Huang +6 more
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Genetic screening of tuberous sclerosis complex in Sicily with a focus on neurological manifestations [PDF]
Scientific ReportsTuberous Sclerosis Complex (TSC) is an autosomal dominant disorder characterized by widespread hamartomas and prominent neurological involvement. It results from pathogenic variants in the TSC1 or TSC2 genes, leading to hyperactivation of the mTOR ...
Andrea Domenico Praticò +13 more
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p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
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Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
doaj +1 more source
Tsc1 regulates tight junction independent of mTORC1 [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance The epithelium barrier is vital for sealing body surface and alimentary spaces, preventing paracellular material diffusion and pathogen invasion. We describe here that tuberous sclerosis complex 1 (Tsc1) controls tight junction (TJ) formation to create and maintain the epithelial barrier, independent of its conventional role in ...
Mingqiang Lai +13 more
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Multifocal micronodular pneumocyte hyperplasia in a patient with undiagnosed tuberous sclerosis: next-generation sequencing of a lung biopsy reveals TSC1 mutation-a case report. [PDF]
J Med Case RepKornafeld A +5 more
europepmc +3 more sources
The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits [PDF]
BMC Biochemistry, 2012 Abstract Background Mutations to the TSC1 and TSC2 genes cause the disease tuberous sclerosis complex. The TSC1 and TSC2 gene products form a protein complex that integrates multiple metabolic signals to regulate the activity of the target of rapamycin (TOR) complex 1 (TORC1) and thereby control cell growth.
Hoogeveen - Westerveld, Marianne +5 more
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Erciyes Medical Journal, 2020 Objective: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome. TSC arises from mutations in either TSC1, at 9q34, or TSC2, at 16p13.3. Skin lesions, such as hypomelanotic macules, facial angiofibromas, shagreen patches, and
Esra Işık +11 more
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Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. [PDF]
PLoS ONE, 2014 TSC1 and TSC2 mutations cause neoplasms in rare disease pulmonary LAM and neuronal pathfinding in hamartoma syndrome TSC. The specific roles of TSC1 and TSC2 in actin remodeling and the modulation of cell motility, however, are not well understood ...
Elena A Goncharova +4 more
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