Results 201 to 210 of about 20,458 (226)

Mutational analysis of TSC1 and TSC2 genes in gangliogliomas

Neuropathology and Applied Neurobiology, 2001
Gangliogliomas constitute the most frequent tumour entity in patients with temporal lobe epilepsy. The characteristic histopathological admixture of glial and neuronal elements, the focal nature and their differentiated phenotype and benign biological behaviour suggest an origin from a developmentally compromised or dysplastic precursor lesion.
Becker, A.J., Lobach, M., Klein, H., Normann, S., Nöthen, M.M., von Deimling, A., Mizuguchi, M., Elger, C.E., Schramm, J., Wiestler, O.D., Blümcke, I.   +10 more
openaire   +3 more sources

Prognostic implication of TSC1 and mTOR expression in gastric carcinoma

Journal of Surgical Oncology, 2014
BackgroundGastric adenocarcinoma is the sixth most common and third most lethal cancer in the world. Except for HER2‐targeted therapy, targeted agents against specific molecules participating in gastric carcinogenesis, including those in the mechanistic target of rapamycin (serine/threonine kinase) (mTOR) pathway have not been proved to be effective ...
Sun-Ju, Byeon, Nayoung, Han, Jiwoon, Choi, Min A, Kim, Woo Ho, Kim   +4 more
openaire   +2 more sources

Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34

Science, 1997
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the widespread development of distinctive tumors termed hamartomas. TSC-determining loci have been mapped to chromosomes 9q34 ( TSC1 ) and 16p13 ( TSC2 ).
van Slegtenhorst, Marjon, de Hoogt, RA (Ronald), Hermans, Caroline, Nellist, Mark, Janssen, ALW (Anneloes), Verhoef, S, Lindhout, D (Dick), van den Ouweland, Ans, Halley, Dicky, Young, J, Burley, M, Jeremiah, S, Woodward, K, Nahmias, J, Fox, M, Ekong, R, Osborne, J, Wolfe, J, Povey, S, Snell, RG, Cheadle, JP, Jones, AC, Tachataki, M, Ravine, D, Sampson, JR, Reeve, MP, Richardson, P, Wilmer, F, Munro, C, Hawkins, TL, Sepp, T, Ali, JBM, Ward, S, Green, AJ, Yates, JRW, Kwiatkowska, J, Henske, EP, Short, MP, Haines, JH, Jozwiak, S, Kwiatkowski, DJ   +40 more
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The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1999
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by seizures, mental retardation, and hamartomatous tumors in multiple organs, including subependymal giant cell astrocytomas, cardiac rhabdomyomas, and renal angiomyolipomas.
T L, Plank, H, Logginidou, A, Klein-Szanto, E P, Henske   +3 more
openaire   +1 more source

TSC1 strikes out on its own

Science Signaling, 2015
TSC1 functions independently of TSC2 and mTORC1 to promote TGF-β signaling.
openaire   +1 more source

Characterization of Exosomes Isolated from the Kidneys of Wild-Type (WT) and Tsc1 Knockout (Tsc1 KO) Mice

Journal of the American Society of Nephrology, 2023
Morgan E. Mackenzie, Kamyar A. Zahedi, Sharon L. Barone, Christos Argyropoulos, Manoocher Soleimani   +4 more
openaire   +1 more source

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

Cell Metabolism, 2019
Fabin Dang, Zhengshuai Liu, Yu Li
exaly  

TSC1

2008
openaire   +1 more source

TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway

Cellular and Molecular Immunology, 2015
Linnan Zhu, Jianxia Peng, Hongbing Zhang   +2 more
exaly  

TSC1

2011
openaire   +1 more source