Results 211 to 220 of about 18,157 (223)

Tsc1 controls the development and function of alveolar macrophages

Biochemical and Biophysical Research Communications, 2018
Alveolar macrophages (AMs) are pivotal for maintaining the lung homeostasis, but how the development and function of AMs regulated remains largely unknown. In the present study, we demonstrated that the number of AMs was controlled by the Tsc1 protein. Cd11c-specific deletion of Tsc1 caused inefficient transition from pre-AMs to AMs in lung, which led ...
Song, Chen, Qiongmei, Yang, Jingru, Liu, Huifang, Huang, Mingxia, Shi, Xiaoming, Feng   +5 more
openaire   +2 more sources

Phosphorylation and binding partner analysis of the TSC1–TSC2 complex

Biochemical and Biophysical Research Communications, 2005
Tuberous sclerosis complex (TSC) is an autosomal dominant benign tumour syndrome caused by mutations to either the TSC1 or TSC2 tumour suppressor gene. The TSC1 and TSC2 gene products, TSC1 and TSC2, form a protein complex that integrates inputs from multiple signalling cascades to inactivate the small GTPase rheb, and thereby inhibit mTOR-dependent ...
Nellist, Mark, Burgers, Peter, van den Ouweland, Ans, Halley, Dicky, Luider, Theo   +4 more
openaire   +3 more sources

TSC1 strikes out on its own

Science Signaling, 2015
TSC1 functions independently of TSC2 and mTORC1 to promote TGF-β signaling.
openaire   +1 more source

TSC1 and TSC2 mutations in tuberous sclerosis, the associated phenotypes and a model to explain observed TSC1/TSC2 frequency ratios

European Journal of Pediatrics, 2002
Tuberous sclerosis (TSC) is a multisystem disease with manifestations in the central nervous system, skin, kidneys, heart, and other visceral organs. The development of TSC is associated with alterations within a gene on chromosome 9q34 ( TSC1) and a gene on chromosome 16p13 ( TSC2).
Langkau, Nicola, Martin, Nicola, Brandt, Regine, Zügge, Karin Louise, Quast, Stefanie, Wiegele, Gerd, Jauch, Anna, Rehm, Marion, Kuhl, Andrea, Mack-Vetter, Monika, Zimmerhackl, Lothar Bernd, Janssen, Bart   +11 more
openaire   +3 more sources

Tissue-Specific Ablation of Tsc1 in Pancreatic Beta-Cells

2011
Tuberous sclerosis complex 1 (TSC1) is a tumor suppressor that associates with TSC2 to inactivate Rheb, thereby inhibiting signaling by the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). mTORC1 stimulates cell growth by promoting anabolic cellular processes, such as translation, in response to growth factors and nutrient signals.
Hiroyuki, Mori, Kun-Liang, Guan
openaire   +2 more sources

Characterization of Exosomes Isolated from the Kidneys of Wild-Type (WT) and Tsc1 Knockout (Tsc1 KO) Mice

Journal of the American Society of Nephrology, 2023
Morgan E. Mackenzie, Kamyar A. Zahedi, Sharon L. Barone, Christos Argyropoulos, Manoocher Soleimani   +4 more
openaire   +1 more source

Acquired Cardiomyopathy Caused by Cardiac Tsc1 Deficiency

Journal of Genetics and Genomics, 2014
Yi, Chen, Fang, Wang, Chunjia, Li, Lianmei, Wang, Hongbing, Zhang, Hongbing, Yan   +5 more
openaire   +2 more sources

TSC1

2008
openaire   +1 more source

TSC1

2011
openaire   +1 more source

TSC1

2017
openaire   +1 more source