Results 21 to 30 of about 18,157 (223)
FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction. [PDF]
PLoS Genetics, 2018 TORC1, a central regulator of cell survival, growth, and metabolism, is activated in a variety of cancers. Loss of the tumor suppressors PTEN and Tsc1/2 results in hyperactivation of TORC1.
Katarzyna Nowak +2 more
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TSC1 (tuberous sclerosis 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TSC1 (tuberous sclerosis 1), with data on DNA, on the protein encoded, and where the gene is implicated.
M van Slegtenhorst, Henske E Petri
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Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice
Journal of Neuroinflammation, 2021 Background Tuberous sclerosis complex 1 (Tsc1) is known to regulate the development and function of various cell types, and RORγt is a critical transcription factor in the immune system.
Yafei Deng +12 more
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TSC1/TSC2 signaling in the CNS [PDF]
FEBS Letters, 2011 Over the past several years, the study of a hereditary tumor syndrome, tuberous sclerosis complex (TSC), has shed light on the regulation of cellular proliferation and growth. TSC is an autosomal dominant disorder that is due to inactivating mutations in TSC1 or TSC2 and characterized by benign tumors (hamartomas) involving multiple organ systems.
Han, Juliette M., Sahin, Mustafa
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Monoallelic germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in tuberous sclerosis complex individuals. [PDF]
PLoS ONE, 2014 Germline and somatic biallelic mutations of the Tuberous sclerosis complex (TSC) 1 and TSC2 gene products cause TSC, an autosomal dominant multifocal hamartomatosis with variable neurological manifestations. The consequences of TSC1 or TSC2 loss in cells
Karolina Pilipow +3 more
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Molecular Autism, 2023 Background Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in the TSC1 or TSC2 genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric disorders ...
Inci S. Aksoylu +12 more
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Oncogenic role of MiR-130a in oral squamous cell carcinoma
Scientific Reports, 2021 Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting as tumor ...
Karthik Mallela +3 more
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BMC Medical Genetics, 2009 Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by the development of hamartomas in a variety of organs and tissues.
den Dunnen Johan T +9 more
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Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells
Cells, 2020 TSC1 is a tumor suppressor that inhibits cell growth via negative regulation of the mammalian target of rapamycin complex (mTORC1). TSC1 mutations are associated with Tuberous Sclerosis Complex (TSC), characterized by multiple benign tumors of ...
Maria V. Guijarro +6 more
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TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice. [PDF]
PLoS ONE, 2012 The PI3K-Akt-mTOR pathway plays crucial roles in regulating both innate and adaptive immunity. However, the role of TSC1, a critical negative regulator of mTOR, in peripheral T cell homeostasis remains elusive.
Lianjun Zhang +10 more
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