Results 51 to 60 of about 31,393 (227)

Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1. [PDF]

, 2018
mTORC1 is a central signaling hub that integrates intra- and extracellular signals to regulate a variety of cellular metabolic processes. Mutations in regulators of mTORC1 lead to neurodevelopmental disorders associated with autism, which is ...
Bateup, Helen S, Benthall, Katelyn N, Ong, Stacie L   +2 more
core   +2 more sources

Correlation between TSC1 gene polymorphism and epilepsy

Experimental and Therapeutic Medicine, 2017
The correlation between tuberous sclerosis complex 1 (TSC1) gene polymorphism and epilepsy was studied. In total, 38 patients with epilepsy treated in People's Hospital of Rizhao from May 2015 to June 2016 were selected as study subjects, as the observation group, 38 healthy people in the same period were selected as the control group. Polymerase chain
Jiang, Xiuli, Chen, Jiajia, Song, Quanjiang, Wang, Weiling, Zhang, Guangyan, Li, Ye   +5 more
openaire   +3 more sources

Vascular Growth in the Fetal Lung [PDF]

, 2011
The structure of the lung is truly remarkable. It is primarily composed of three branched tubular networks (the airway, pulmonary artery and vein, bronchial artery and vein) which supply blood and air to the site of gas exchange and which maintain ...
Land, Stephen
core   +4 more sources

Tsc1 deletion in Purkinje neurons disrupts the axon initial segment, impairing excitability and cerebellar function

Neurobiology of Disease
Loss-of-function mutations in tuberous sclerosis 1 (TSC1) are prevalent monogenic causes of autism spectrum disorder (ASD). Selective deletion of Tsc1 from mouse cerebellar Purkinje neurons has been shown to cause several ASD-linked behavioral ...
Samuel P. Brown, Achintya K. Jena, Joanna J. Osko, Joseph L. Ransdell   +3 more
doaj   +1 more source

Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. [PDF]

PLoS ONE, 2015
Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis.
Heidi L Kenerson, Savitha Subramanian, Rebecca McIntyre, Machiko Kazami, Raymond S Yeung   +4 more
doaj   +1 more source

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity [PDF]

, 2019
The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is ...
Backe, Sarah J, Baker-Williams, Alexander J, Bourboulia, Dimitra, Bratslavsky, Gennady, Bratslavsky, Michael S, Hughes, Michael, Jacob, Joseph M, Mollapour, Mehdi, Sager, Rebecca A, Shapiro, Oleg, Wong, Michael, Woodford, Mark R   +11 more
core   +1 more source

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]

, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui, Chandel, Navdeep S, DeBerardinis, Ralph J, Dickerson, Kathryn E, Gu, Zhimin, Hu, Zeping, Li, Dan, Li, Mushan, Liu, Xin, Ni, Min, Shao, Zhen, Signer, Robert AJ, Weinberg, Samuel E, Xu, Jian, Zhang, Yuannyu, Zhou, Feng   +15 more
core   +1 more source

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy [PDF]

Nature Medicine, 2013
Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke. We hypothesized that studying the molecular determinants of endogenous neuroprotection in two well-established paradigms, the resistance of CA3 hippocampal ...
Papadakis, M, Hadley, G, Xilouri, M, Hoyte, L, Nagel, S, McMenamin, M, Tsaknakis, G, Watt, S, Drakesmith, C, Chen, R, Wood, M, Zhao, Z, Kessler, B, Vekrellis, K, Buchan, A   +14 more
openaire   +4 more sources

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers

Molecular Cancer, 2006
Background Polymorphisms or mutations in hypoxia inducible factor-1 alpha (HIF-1alpha) that increases its activity and stability under normoxia have recently been identified.
Nikitakis Nikolaos G, Ord Robert A, Parashar Pallavi, Norris Kathleen, Hebert Carla, Sauk John J   +5 more
doaj   +1 more source