The variation of AkT/TSC1–TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats
Experimental and Molecular Pathology, 2009 The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats.We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes.
Yin Chen +3 more
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Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins. [PDF]
, 2015 BACKGROUND: Tuberous sclerosis complex is a multisystem genetic disease, caused by mutation in the TSC1 or TSC2 genes, associated with many features, including intellectual disability (ID).
de Vries, Petrus J +5 more
core +2 more sources
Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. [PDF]
PLoS ONE, 2015 Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis.
Heidi L Kenerson +4 more
doaj +1 more source
Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]
, 2017 Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad +16 more
core +2 more sources
Retraction: Drosophila yakuba – Tsc1
, 2021 Lose, B; Myers, A; Fondse, S; Alberts, I; Stamm, J; Youngblom, JJ; Rele, CP; Reed, LK (2021). Private: Drosophila yakuba – Tsc1. microPublication Biology. 10.17912/micropub.biology.000407, was mistakenly published before peer-review was completed. This was not an intentional . The published version of the article was made removed from public viewing on
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Stochastic Model of Tsc1 Lesions in Mouse Brain
PLoS ONE, 2013 Tuberous sclerosis complex (TSC) is an autosomal dominant disorder due to mutations in either TSC1 or TSC2 that affects many organs with hamartomas and tumors. TSC-associated brain lesions include subependymal nodules, subependymal giant cell astrocytomas and tubers.
Shilpa, Prabhakar +12 more
openaire +6 more sources
Evidence for population variation in TSC1 and TSC2 gene expression [PDF]
BMC Medical Genetics, 2011 AbstractBackgroundTuberous sclerosis complex (TSC) is an autosomal dominant neurogenetic disorder caused by mutations in one of two genes,TSC1orTSC2, which encode the proteins hamartin and tuberin, respectively [1–3]. Common features of TSC include intractable epilepsy, mental retardation, and autistic features.
Stephen G. Rice +5 more
openaire +4 more sources
TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. [PDF]
PLoS ONE, 2015 Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system.
Xinxin Ci +10 more
doaj +1 more source
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity [PDF]
, 2019 The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is ...
Backe, Sarah J +11 more
core +1 more source
AMPK in the central nervous system: physiological roles and pathological implications [PDF]
, 2016 5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain.
Fioramonti, Marco +6 more
core +1 more source