Results 161 to 170 of about 40,807 (310)

Establishment of Tsc2-deficient rat embryonic stem cells

International Journal of Oncology, 2015
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by TSC1 or TSC2 mutations. TSC causes the development of tumors in various organs such as the brain, skin, kidney, lung, and heart. The protein complex TSC1/2 has been reported to have an inhibitory function on mammalian target of rapamycin complex 1 (mTORC1).
Eri Nakamura, Toshiyuki Kobayashi, Shigeo Horie, Hajime Arai, Fumio Kanai, Okio Hino, Yoshitaka Ito, Haruna Kawano, Setsuo Takai, Norihiro Tada   +9 more
openaire   +3 more sources

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Generation of a TSC2 knockout embryonic stem cell line by CRISPR/Cas9 editing

Stem Cell Research
Tuberous Sclerosis Complex (TSC) is a severe developmental disorder with various clinical effects, primarily caused by TSC2 gene mutations, often involving loss of function(Henske,et al., 2016).To explore role of TSC2 in human heart development, we ...
Siyao Zhang, Jiaqi Fan, Hairui Sun, Xiaoyan Hao, Yihua He   +4 more
doaj  

TSC2-mutant uterine sarcomas with JAZF1-SUZ12 fusions demonstrate hybrid features of endometrial stromal sarcoma and PEComa and are responsive to mTOR inhibition

Modern Pathology, 2021
S. Chiang, V. Vasudevaraja, J. Serrano, C. Stewart, E. Oliva, Amir Momeni-Boroujeni, A. Jungbluth, A. Da Cruz Paula, E. D. da Silva, B. Weigelt, Kay J. Park, R. Soslow, R. Murali, Lora H. Ellenson, R. Benayed, M. Ladanyi, N. Abu-Rustum, M. Dickson, Seth Cohen, C. Aghajanian, M. Hensley, Cheng-Han Lee, M. Snuderl, J. Konner   +23 more
semanticscholar   +1 more source

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization

The Journal of Pathology, Volume 266, Issue 4-5, Page 421-434, August 2025.
Abstract Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, its nature remains unclear. This study aims to define the clinicopathological and molecular profiles of a
Antonio Pea, Michele Bevere, Anastasios Gkountakos, Davide Pasini, Denise Fiorini, Andrea Mafficini, Stela Golovco, Michele Simbolo, Serena Pedron, Concetta Sciammarella, Paola Mattiolo, Aldo Mombello, Manuela Villanova, Carlotta Franzina, Francesca Masetto, Calogero Ciulla, Nicola Sperandio, Kohei Fujikura, Masha S. Ahadi, Jaswinder S. Samra, Amber L. Johns, Joanne Verheij, Martijn W.J. Stommel, Hjalmar van Santvoort, Leonor Schubert Santana, Giuseppe Malleo, Michele Milella, Lodewijk A. A. Brosens, Laura D. Wood, David K. Chang, Riccardo De Robertis, Mirko D'Onofrio, Anthony J. Gill, Roberto Salvia, Vincenzo Corbo, Rita T. Lawlor, Aldo Scarpa, Claudio Luchini   +37 more
wiley   +1 more source

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR [PDF]

, 2003
Hongbing Zhang, Gregor Cicchetti, Hiroaki Onda, Henry Koon, Kirsten Asrican, Natalia Bajraszewski, Francisca Vázquez, Christopher L. Carpenter, David J. Kwiatkowski   +8 more
openalex   +2 more sources

Comparison of three rapamycin dosing schedules in A/J Tsc2^+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

Journal of Translational Medicine, 2010
Background Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart.
Dabora Sandra L, Nobil Alison, Woodrum Chelsey   +2 more
doaj   +1 more source

Identification of a nonsense mutation at the 5' end of the TSC2 gene in a family with a presumptive diagnosis of tuberous sclerosis complex. [PDF]

, 1996
Radek Vrtěl, Senno Verhoef, K. Bouman, Magitha M. Maheshwar, Mark Nellist, Anthonie J. van Essen, Petra L. Bakker, Caroline Hermans, Margreet Th.E. Bink‐Boelkens, Ruurd M. van Elburg, M. Hoff, Dick Lindhout, Julian R. Sampson, D. J. J. Halley, A M van den Ouweland   +14 more
openalex   +1 more source

Toward chemotherapy for Tsc2-mutant renal tumor.

Proceedings of the Japan Academy, Series B, 2003
Recent genetic studies of Drosophila melanogaster and subsequent biochemical analysis in mammalian cells revealed that products of tuberous sclerosis genes, TSC1 and TSC2, regulate insulin signaling via suppression of p70 ribosomal S6 subunit-kinase (S6K) activity.
Hiroyuki Adachi, Okio Hino, Toshiyuki Kobayashi, Youko Hirayama, Hiroaki Mitani   +4 more
openaire   +3 more sources

Involvement of KEAP1/NRF2 pathway in non‐BRAF mutated squamous cell carcinoma of the thyroid

The Journal of Pathology, Volume 266, Issue 4-5, Page 481-494, August 2025.
Abstract Squamous cell carcinoma (SCC) of the thyroid is a rare tumor that is classified as an anaplastic thyroid cancer (ATC) due to its similar unresponsiveness to chemoradiotherapy and an outstandingly poor prognosis. Due to its rarity, current knowledge about this tumor is mostly based on single‐case reports.
Elin Schoultz, Jakob Dahlberg, Lisa M Nilsson, Jozefina J Dzanan, Therese Carlsson, Niklas Dahr, Ellinor Andersson, Ghayeb Muhammad, Andreas Muth, Erik Elias, Henrik Fagman, Volkan I Sayin, Jonas A Nilsson, Mikael Nilsson   +13 more
wiley   +1 more source