Results 61 to 70 of about 8,987 (189)

Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution.

PLoS Neglected Tropical Diseases, 2019
BackgroundThe hyaluronidase enzyme is generally known as a spreading factor in animal venoms. Although its activity has been demonstrated in several organisms, a deeper knowledge about hyaluronidase and the venom spreading process from the bite/sting ...
Bárbara Bruna Ribeiro de Oliveira-Mendes, Sued Eustáquio Mendes Miranda, Douglas Ferreira Sales-Medina, Bárbara de Freitas Magalhães, Yan Kalapothakis, Renan Pedra de Souza, Valbert Nascimento Cardoso, André Luís Branco de Barros, Clara Guerra-Duarte, Evanguedes Kalapothakis, Carolina Campolina Rebello Horta   +10 more
doaj   +1 more source

Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus

Emerging Infectious Diseases, 2011
We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology.
Els van der Meijden, Siamaque Kazem, Manda M. Burgers, Rene Janssens, Jan Nico Bouwes Bavinck, Hester E. de Melker, Mariet C.W. Feltkamp   +6 more
doaj   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, Volume 159, Issue 7, Page 1715-1734, 1 October 2026.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Computationally Driven Advances in Cu‐CNT On‐Chip Interconnect Materials: From First Principles to Machine Learning

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
A multiscale framework integrating electronic, mechanical, and thermal analysis with machine learning to optimize carbon nanotube interconnects. As the component dimensions in integrated circuits shrink to extreme scales, the complexity of interconnect systems is increasing significantly, necessitating an urgent and comprehensive upgrade of ...
Changhong Zhang, Jie Liang, Yi Li, Zhenyu Wang, Haoyuan Li, Zhen Yuan, Jiuren Zhou, Rongmei Chen, Wensheng Zhao, Lei Zhang, Hanshen Xin, Jianhua Zhang   +11 more
wiley   +1 more source

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source

Engineering resistance against Tobacco streak virus (TSV) in sunflower and tobacco using RNA interference

Biologia Plantarum, 2012
The coat protein (CP) gene of Tobacco streak virus (TSV) from sunflower (Helianthus annuus L.) was amplified, cloned and sequenced. A 421 bp fragment of the TSV coat protein gene was amplified and a gene construct encoding the hairpin RNA (hpRNA) of the ...
K. Pradeep, V. K. Satya, M. Selvapriya, A. Vijayasamundeeswari, D. Ladhalakshmi, V. Paranidharan, R. Rabindran, R. Samiyappan, P. Balasubramanian, R. Velazhahan   +9 more
doaj   +1 more source

Validation of the International Weed Genomics Consortium genome annotation pipeline through reannotation of the model species Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract The International Weed Genomics Consortium (IWGC) has sequenced and annotated the genomes of over 30 weed species, generating genomic resources to understand their biology, evolution, and adaptation. The objective of this study was to evaluate the semi‐automated, isoform sequencing (Iso‐seq)‐based, IWGC genome annotation pipeline by ...
Luan Cutti, Daniel Fernando da Silva Filho, Geisson Edwin Guadir Lara, Jessica Matheson, Nicholas A. Johnson, Jacob Montgomery, Nathan Hall, Brent Murphy, Todd A. Gaines, Eric L. Patterson   +9 more
wiley   +1 more source

An Integrated Process‐Based Approach for Interpreting Precipitation Isotopes Using North‐Central Texas as a Testbed

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 16, 28 August 2026.
Abstract The isotopic composition of precipitation reflects the combined influences of moisture sources, rainout history, and convective intensity, but the relative importance of these controls varies among regions and remains poorly understood in continental settings.
Juan Camacho, Ricardo Sánchez‐Murillo
wiley   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Study on the Effects and Mechanisms of Sea Buckthorn Fruit Pulp in Improving Polycystic Ovary Syndrome

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Sea buckthorn pulp improves metabolic and reproductive dysfunction in a letrozole‐induced PCOS mouse model and is associated with modulation of the PI3K/AKT/mTOR signaling pathway. ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by ovarian dysfunction, hyperandrogenism, and insulin resistance.
Han Xiaoya, Yang Yuanyuan, Peng Qingjie, Chen Xiaojiang, Ma Cunling, Li Na, Tian Xiaofan, Wu Xin, Liu Hetao, He Rui   +9 more
wiley   +1 more source