Results 101 to 110 of about 35,493 (223)
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes
The FEBS Journal, EarlyView.During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb +4 more
wiley +1 more source
Seventh Åland Island Meeting on von Willebrand Disease
Haemophilia, EarlyView.ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila +17 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Plain Language Summary Migraine with aura can mimic a stroke, making diagnosis difficult and sometimes leading to unnecessary treatment in the acute setting. We found that some patients with migraine with aura show characteristic changes on brain perfusion CT scans, particularly in men and those with speech symptoms, which can be better detected using ...
Lucía Gómez Martín de la Escalera +8 more
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Objectives To assimilate data from individual randomised trials and perform a pooled analysis of short‐term outcomes of pulpotomy compared with root canal treatment (RCT) for teeth with symptomatic irreversible pulpitis (SIRP). Methods Randomised trials were conducted in eight countries using a standardised clinical protocol and outcome ...
I. A. El Karim +16 more
wiley +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Technological integration into teaching offers significant pedagogical potential, yet it can also intensify the challenge of addressing systemic barriers to inclusion. This issue is especially important for teaching‐focused academics (TAs), who are increasingly leading classroom instruction and translating institutional digital priorities into
Hao Tran, Thao Thi Phuong Nguyen
wiley +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Moderately hypofractionated definitive‐intent radiotherapy protocols can be used for canine intracranial meningiomas to shorten overall treatment time while maintaining tumour control and limiting normal tissue toxicity. This retrospective study evaluated oncologic outcomes, toxicity, and radiation dose‐volume‐related prognostic factors in ...
Carlotta Ahrens +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler +6 more
wiley +1 more source