Results 91 to 100 of about 150,674 (263)

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]

, 2014
BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Topolewski, Katharyn   +3 more
core   +3 more sources

Perinatal outcomes in normotensive versus hypertensive HELLP syndrome

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare maternal and neonatal outcomes between women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome with and without associated hypertension. Methods This was a retrospective cohort study at a tertiary university‐affiliated medical center including all singleton HELLP cases >24 weeks gestation (January ...
Matan Anteby, Keren‐Or Wertheimer, Omri Dominsky, Liran Hiersch, Yariv Yogev   +4 more
wiley   +1 more source

Bottom-quark effects in Higgs production at intermediate transverse momentum

Journal of High Energy Physics, 2018
We provide a precise description of the Higgs boson transverse momentum distribution including top and bottom quark contributions, that is valid for transverse momenta in the range m b  ≲ p ⊥ ≲ m t , where m b and m t are the bottom and top quark masses.
Fabrizio Caola, Jonas M. Lindert, Kirill Melnikov, Pier Francesco Monni, Lorenzo Tancredi, Christopher Wever   +5 more
doaj   +1 more source

A modified Oster-Murray-Harris mechanical model of morphogenesis [PDF]

, 2013
There are two main modeling paradigms for biological pattern formation in developmental biology: chemical prepattern models and cell aggregation models. This paper focuses on an example of a cell aggregation model, the mechanical model developed by Oster,
Benjamin L. Vaughan, David Kay, Harris A. K., Murray J. D., Oster G. F., Philip K. Maini, Ruth E. Baker   +6 more
core   +1 more source

The “5L” framework of diagnostic reasoning: A stepwise scaffold to support clinician educators

Journal of Hospital Medicine, EarlyView.
Abstract Diagnostic reasoning (DR) is a core clinical skill, yet its teaching remains variable. We introduce the “5L” framework as a bedside teaching scaffold that gives educators and learners a shared, stepwise set of prompts for DR during individual encounters. By asking, “What's Lethal? What's Likely? What's Logical? What's Lurking?
Olivia Brumfield, Amal Mohamed, Shuhan He, Cory Rohlfsen   +3 more
wiley   +1 more source

Szu-Feng Chen, Assistant Professor, Department of Theatre and Dance, travels to Singapore [PDF]

, 2012
Professor Szu-Feng Chen was invited by The Theatre Practice (TTP) in Singapore to create set and costume design for Lao Jiu: The Musical, its feature musical production for the Singapore Kuo Pao Kun Festival.I was invited by The Theatre Practice (TTP) in
Chen, Szu-Feng
core   +1 more source

Theory of the beta-type Organic Superconductivity under Uniaxial Compression

, 2011
We study theoretically the shift of the superconducting transition temperature (Tc) under uniaxial compression in beta-type organic superconductors, beta-(BEDT-TTF)2I3 and beta-(BDA-TTP)2X[X=SbF6,AsF6], in order to clarify the electron correlation, the ...
Beckmann D., Bickers N. E., Bickers N. E., Choi E. S., Ichimura K., Ichimura K., Ito H., Ito H., Kang W., Kashiwaya S., Kino H., Kino H., Koikegami S., Komatsu T., Kondo H., Kontani H., Kontani H., Kuroki K., Maesato M., Maesato M., Mori T., Mori T., Murata K., Nomura K., Nonoayama Y., Powell B. J., Shimizu Y., Suzuki T., Tanaka Y., Tanino H., Urayama H., Watanabe T., Yamada J., Yasuzuka S.   +33 more
core   +1 more source

Reduced sensitivity to visual looming inflates the risk posed by speeding vehicles when children try to cross the road [PDF]

, 2011
Almost all locomotor animals respond to visual looming or to discrete changes in optical size. The need to detect and process looming remains critically important for humans in everyday life.
Catherine Purcell, Damian R. Poulter, John P. Wann, Toroyan T.   +3 more
core   +3 more sources

Cytoreductive Surgery in Patients With Metastatic Succinate Dehydrogenase‐Deficient Gastrointestinal Stromal Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Succinate dehydrogenase‐deficient (SDH‐deficient) gastrointestinal stromal tumors (GIST) are characterized by variable disease biology with poor responses to traditional tyrosine kinase inhibitors. The role of surgical intervention has been highly debated.
Katherine Y. Chen, Mark Antkowiak, Ashwyn K. Sharma, Robert Mallory, Adam M. Burgoyne, Paul T. Fanta, Jason K. Sicklick   +6 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source