Results 141 to 150 of about 150,674 (263)

Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses

Allergology International
Background: Basophils, despite being the least common granulocytes, play crucial roles in type 2 immune responses, such as chronic allergic inflammation and protective immunity against parasites.
Junya Ito, Kensuke Miyake, Tomoki Chiba, Kazufusa Takahashi, Yutaro Uchida, Perry J. Blackshear, Hiroshi Asahara, Hajime Karasuyama   +7 more
doaj   +1 more source

Autoethnography as a Research Methodology in TESOL

TESOL Quarterly, Volume 60, Issue 2, Page 867-886, June 2026.
Abstract In this article, I discuss autoethnography as a qualitative research methodology that has been increasingly adopted by scholars in TESOL in the last decade. My goal is to introduce this methodology to colleagues who are preparing to use autoethnography in their research and I expect that introduction to take them to other resources in the ...
Bedrettin Yazan
wiley   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Positioning of Melflufen in Heavily Pretreated RRMM Patients: Real‐World Evidence in a Rapidly Evolving Therapeutic Landscape

European Journal of Haematology, Volume 116, Issue 6, Page 928-936, June 2026.
ABSTRACT Modern therapies have clearly marked the history of multiple myeloma (MM), leading to undisputed advantages in terms of sustained responses and prolonged survival, while progressively improving patients' quality of life. Nonetheless, disease recurrence and resistance to available therapies underscore the importance of identifying additional ...
K. Mancuso, S. Masci, M. Talarico, A. Vitale, S. Barbato, V. Solli, M. Puppi, I. Rizzello, L. Pantani, P. Tacchetti, M. Iezza, R. Restuccia, I. Sacchetti, E. Manzato, S. Ghibellini, S. Armuzzi, B. Taurisano, M. Cavo, E. Zamagni   +18 more
wiley   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

A knock-in tristetraprolin (TTP) zinc finger point mutation in mice: Comparison with complete TTP deficiency [PDF]

, 2018
Blackshear, Perry J, Faccio, Roberta, Lai, Wi S, Qiu, Lianqun, Stumpo, Deborah J   +4 more
core   +2 more sources

Estrogen Deprivation During Primate (Papio anubis) Pregnancy: Impact on Systemic Microvascular Flow and Cardiovascular Development and Function After Birth in Offspring

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT Background Suppressing estradiol (E2) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin‐mediated glucose uptake, and induces insulin resistance. We examined whether E2 deprivation also impairs microvascular flow and cardiac function.
Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht   +4 more
wiley   +1 more source

Real-World Analysis of Clinical Characteristics, Treatment Outcomes, and the Novel Predictive Model for Patients with Thrombotic Thrombocytopenic Purpura (TTP) and TTP-Like Syndrome

Vascular Health and Risk Management
Mengya Lv,1 Xing Hu,2 Lijun Zhu,2 Hui Xu,2 Erling Chen,2 Na Zhao,2 Juan Tong,2 Changcheng Zheng1,2 1Department of Hematology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China; 2Department of Hematology ...
Lv M, Hu X, Zhu L, Xu H, Chen E, Zhao N, Tong J, Zheng C   +7 more
doaj  

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1385-1396, May 2026.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Probable Catastrophic Antiphospholipid Syndrome Overlapping Hematological Abnormalities: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT A young South Asian woman presented four weeks post‐miscarriage with fever, jaundice, edema, headache, neurological deficits, anemia, thrombocytopenia, proteinuria, hematuria, splenic infarct, and cerebral venous sinus thrombosis. Positive beta‐2 glycoprotein IgG and lupus anticoagulant supported probable CAPS.
Faseeh Ullah, Maryam Tariq, Marwa Farzand, Irha Riaz, Rizwan Rasol Khan, Kritick Bhandari   +5 more
wiley   +1 more source