Results 31 to 40 of about 35,493 (223)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Transregionalism in US Foreign Policy: Comparative Analysis of TPP and TTIP Geopolitics

Сравнительная политика, 2017
The decision of US President Donald Trump to withdraw from the Trans-Pacifi c Partnership and the sluggish negotiations on Transatlantic Trade and Investment Partnership have fueled the debate on the future trajectories of American foreign policy in its ...
Denis A. Kuznetsov
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Strange or estranged bedfellows? Discerning the Taliban-Pakistan relationship [PDF]

Revista UNISCI
The Afghan Taliban and Pakistan are often touted as two sides of the same coin, given the latter’s pivotal role in supporting the movement since its emergence in 1994, and subsequently in resurrecting it as a potent insurgent force against NATO.
Raghav Sharma
doaj   +1 more source

Designed Lewis Acid–Base Passivation for High Performance Perovskite Solar Cells

Advanced Functional Materials, EarlyView.
ABSTRACT Silicon's high cost and long energy payback time remain major barriers to the global expansion of solar power. In contrast, metal–halide perovskites offer abundant, solution‐processable absorbers, and have achieved efficiencies of 25%–30%, positioning them as strong competitors to silicon.
Afna Manaf, Hiba Shahulhameed, Bhabani Sankar Swain, Shengzhong (Frank) Liu, Adel Najar   +4 more
wiley   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Bottom-quark effects in Higgs production at intermediate transverse momentum

Journal of High Energy Physics, 2018
We provide a precise description of the Higgs boson transverse momentum distribution including top and bottom quark contributions, that is valid for transverse momenta in the range m b  ≲ p ⊥ ≲ m t , where m b and m t are the bottom and top quark masses.
Fabrizio Caola, Jonas M. Lindert, Kirill Melnikov, Pier Francesco Monni, Lorenzo Tancredi, Christopher Wever   +5 more
doaj   +1 more source

From Intelligence gathering to Cyber Threat Detection [PDF]

Romanian Intelligence Studies Review, 2023
Intelligence plays a key role in the detection and neutralisation of threat actors in cyberspace, particularly when dealing with advanced ones. However, the relationship between intelligence and the final detection capabilities is not well–defined in ...
Antonio VILLALON-HUERTA, Ismael RIPOLL-RIPOLL, Héctor MARCO-GISBERT   +2 more
doaj  

A closer look at isodoublet vector leptoquark solution to the R D ∗ $$ {R}_{D^{\left(\ast \right)}} $$ anomaly

Journal of High Energy Physics, 2023
We discuss a model with a SU(2) L doublet vector leptoquark (LQ), motivated by the recent experimental results relating to the lepton universality of B ¯ $$ \overline{B} $$ → D (*) τ ν ¯ τ $$ \tau {\overline{\nu}}_{\tau } $$ .
Syuhei Iguro, Yuji Omura
doaj   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source