Results 11 to 20 of about 51,249 (253)

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer [PDF]

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +2 more sources

Rituximab in the treatment of TTP

Hematology, 2012
Thrombotic thrombocytopenic purpura (TTP) is an acute life threatening disorder, for which mortality remains relatively unchanged since the introduction of plasma therapy. Improved understanding of the pathophysiology has identified that the majority of cases result from antibodies directed against ADAMTS 13, which is required to cleave von Willebrand ...
Marie Scully
exaly   +3 more sources

ADAMTS13 in the New Era of TTP

International Journal of Molecular Sciences
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening, often immune-mediated disease that affects 2–13 persons per million per year. Hemolytic anemia, thrombocytopenia, and end-organ damage due to the formation of microthrombi are characteristic of TTP.
Anna Papakonstantinou, Panagiotis Kalmoukos, Aikaterini Mpalaska, Evaggelia-Evdoxia Koravou, Eleni Gavriilaki   +4 more
openaire   +3 more sources

Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005 [PDF]

, 2008
The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management
Todd, W.T.A., Beattie, T.J., Pollock, K.G.J., Young, D.   +3 more
core   +4 more sources

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors : a single-institution experience [PDF]

, 2010
Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and ...
Douglas, K.W., Green, R., Douglas, Kenneth W., Pollock, K.G.J., Pollock, Kevin G.J., Catlow, Jamie, Young, D., Catlow, J., Young, David, Green, Rachel   +9 more
core   +4 more sources

Extremely High-Throughput Parallel Microfluidic Vortex-Actuated Cell Sorting

Micromachines, 2021
We demonstrate extremely high-throughput microfluidic cell sorting by making a parallel version of the vortex-actuated cell sorter (VACS). The set-up includes a parallel microfluidic sorter chip and parallel cytometry instrumentation: optics, electronics
Alex A. Zhukov, Robyn H. Pritchard, Mick J. Withers, Tony Hailes, Richard D. Gold, Calum Hayes, Mette F. la Cour, Fred Hussein, Salman Samson Rogers   +8 more
doaj   +1 more source

To TTP or not to TTP?: Exploiting TTPs to Improve ML-based Malware Detection

2023 IEEE International Conference on Cyber Security and Resilience (CSR), 2023
In the last decade, machine learning (ML) methods have increasingly been applied to the task of malware detection. While these approaches have surely demonstrated their effectiveness, they still present limitations, some of which are a consequence of their purely data-driven nature.
Yashovardhan Sharma, Eleonora Giunchiglia, Simon Birnbach, Ivan Martinovic   +3 more
openaire   +1 more source

On the interference of ggH and c ¯ cH $$ \overline{\mathrm{c}}\mathrm{cH} $$ Higgs production mechanisms and the determination of charm Yukawa coupling at the LHC

Journal of High Energy Physics, 2021
Higgs boson production in association with a charm-quark jet proceeds through two different mechanisms — one that involves the charm Yukawa coupling and the other that involves direct Higgs coupling to gluons.
Wojciech Bizoń, Kirill Melnikov, Jérémie Quarroz   +2 more
doaj   +1 more source

Thrombotic thrombocytopaenic purpura in the era of HIV: A single-centre experience

Southern African Journal of HIV Medicine, 2023
Background: Thrombotic thrombocytopaenia purpura (TTP) is a rare disorder which carries a high mortality. HIV is an important cause of TTP. Objectives: We assessed the presentation and response to plasma exchange (PEX) by HIV status.
Yusuf Moola, Zaheera Cassimjee, Chandni Dayal, Sheetal Chiba, Adekunle Ajayi, Malcolm Davies   +5 more
doaj   +1 more source

Towards ruling out the charged Higgs interpretation of the R D ∗ $$ {R}_{D^{\left(\ast \right)}} $$ anomaly

Journal of High Energy Physics, 2022
Motivated by the notorious anomaly in the lepton flavor universality ratios R D ∗ $$ {R}_{D^{\left(\ast \right)}} $$ , we study the sensitivity of the Large Hadron Collider (LHC) to a low-mass charged Higgs boson H − lighter than 400 GeV in a generic two
Monika Blanke, Syuhei Iguro, Hantian Zhang   +2 more
doaj   +1 more source