Results 181 to 190 of about 9,283 (249)
British Journal of Clinical Pharmacology, EarlyView.Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman +9 more
wiley +1 more source
BMEMat, EarlyView.MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen +10 more
wiley +1 more source
BMEMat, EarlyView.Schematic illustration of preparation of injectable H/G@Co@miR‐206 hydrogel for efficient skeletal muscle regeneration in cardiotoxin‐induced skeletal muscle injury SD rat model. Abstract The effective treatment of acute skeletal muscle injuries remains challenging, necessitating therapeutic strategies that concurrently reestablish vascular perfusion ...
Zhengzhe Han +9 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Luminescent coordination polymers of Group 1 (Li, K, Cs) and 2 (Mg─Ba) cations with gold(I) iso‐maleonitriledithiolate ({Au2[S2C = C(CN)2]}2−) units were prepared; 1‐D aurophilic chains are present in all cases. The structures strongly depend on cation charge and size, with N‐cyano coordination observed in the Gp 1 and larger Gp 2 cations. Increasingly
Jefferson A. Pells +2 more
wiley +1 more source
The Role of Iron‐Hyponitrite Intermediates in Biology and Insights From Synthetic Model Complexes
Chemistry – A European Journal, EarlyView.Despite the difference in active site architecture, NO reduction by different NOR enzymes is expected to be linked by a common intermediate: hyponitrite (N2O22−). However, experimentally, very little is known about the coordination chemistry of iron with hyponitrite and the expected Fe‐hyponitrite intermediates.
Michael O. Lengel, Nicolai Lehnert
wiley +1 more source
Chemistry – A European Journal, EarlyView.The synergic action of ascorbic acid and NHC^N ligands enables Au(I) oxidation with electron‐rich aryldiazonium salts. ABSTRACT The synergistic action of ascorbic acid and NHC^N ligands enables the challenging oxidation of Au(I) with electron‐rich aryldiazonium salts in the absence of a cocatalyst and/or irradiation. EPR, NMR, and x‐ray analyses reveal
Paula G. Cárdenas‐Cárdenas +7 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen +2 more
wiley +1 more source
Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats
ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén +16 more
wiley +1 more source