Results 131 to 140 of about 1,646,835 (267)

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

open access: yesAdvanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong   +17 more
wiley   +1 more source

Youngstown Sheet and Tube Company's South Chicago Works

open access: yes, 1920
The blast furnaces at Youngstown Sheet and Tube Company's South Chicago Works in Chicago, Illinois, ca. 1920-1929. James A. Campbell's success in steel manufacturing was not limited to the Youngstown regional area.
Youngstown Sheet and Tube Company
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Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

open access: yesAdvanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang   +19 more
wiley   +1 more source

Programmable Topological Magnetic Textures in Above‐Room‐Temperature 2D Ferromagnet Fe3GaTe2

open access: yesAdvanced Science, EarlyView.
This work demonstrates the programmable generation and deterministic modulation of magnetic skyrmion bags with high‐order topological numbers in the above‐room‐temperature 2D ferromagnet Fe3GaTe2 (FGaT) via current‐pulse control. Furthermore, highly efficient electrical manipulation and current‐driven parallel motion of these high‐order topological ...
Hanqing Shi   +8 more
wiley   +1 more source

Youngstown Sheet and Tube Company's Campbell Works blast furnace

open access: yes, 1920
A view of Youngstown Sheet and Tube Company's blast furnaces at the Campbell Works, ca. 1920-1929. Founded in 1900, Youngstown Sheet and Tube established an integrated steel plant in East Youngstown, which would later become Campbell, Ohio.
Youngstown Sheet and Tube Company
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A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

Youngstown Sheet and Tube Company's Indiana Harbor Works

open access: yes, 1920
Youngstown Sheet and Tube Company's Indiana Harbor Works standing on the shores of Lake Michigan in East Chicago, Indiana, ca. 1920-1929. James A. Campbell purchased the Indiana Harbor Works in 1923 as part of an expansion of the Youngstown Sheet and ...
Youngstown Sheet and Tube Company
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Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

open access: yesAdvanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang   +14 more
wiley   +1 more source

Youngstown Sheet and Tube Company's Rod and Wire Plant

open access: yes, 1910
This photograph shows the interior of Youngstown Sheet and Tube Company's Rod and Wire Plant in Struthers, Ohio, ca. 1910-1919. As president of Youngstown Sheet and Tube, James A.
Youngstown Sheet and Tube Company
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