Results 121 to 130 of about 95,519 (238)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 4, April 2026.The anticancer activity of 5‐FU modified with mannose containing 1,2,3‐triazole compound in MCF‐7 breast cancer cells were revealed in this study. While 5‐FU caused cytotoxicity in both cancerous and healthy cells, 5‐FUD‐Man showed selective cytotoxicity.
Ebru Şanci +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu +7 more
wiley +1 more source
Immunology, Volume 177, Issue 4, Page 810-823, April 2026.RNA‐seq of lungs and livers from Mycobacterium tuberculosis ‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and
Felipe T. Lima +9 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Cornus officinalis (CO) is a traditional herbal medicine renowned in Traditional Chinese Medicine (TCM) for its properties of tonifying the liver and kidney and replenishing vital essence. Meanwhile, wine‐processed CO (pCO) exhibits superior pharmacological effects, including anti‐inflammatory, antioxidant and anti‐fibrotic activities. However,
Yongsheng Fu +4 more
wiley +1 more source
Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi
ChemMedChem, Volume 21, Issue 6, 27 March 2026.Aspartate transcarbamoylase (ATC) catalyzes the committed and rate‐limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by ...
Siyao Chen +8 more
wiley +1 more source
Development of a high-throughput microsatellite typing approach for forensic and population genetic analysis of wild and domestic African Bovini [PDF]
, 2008 Conservation management and forensic traceability of African buffalo and cattle rely on the timely provision of unbiased and accurate genetic information.
Bastos, A.D.S. +6 more
core +1 more source
Quinic Acid and Synthetic Derivatives in Medicinal Chemistry
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel +2 more
wiley +1 more source
Prevalence of bovine tuberculosis in the Aksu Region of Xinjiang, China, between 1985 and 2016
Arquivo Brasileiro de Medicina Veterinária e ZootecniaPrevalence of bovine tuberculosis infection in cattle in Aksu Prefecture determined by intradermal tuberculin skin test (TST), between 1985 and 2016. Cattle were analyzed according to region, feeding pattern, herds and age. A total of 890,009 cattle were
Y.H. Liu +6 more
doaj +1 more source