Results 131 to 140 of about 828,953 (227)

Pharmacogenetic hSLCO1B1*14‐Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response

open access: yesClinical and Translational Science, Volume 19, Issue 1, January 2026.
Summary of SLCO1B1 impact on methotrexate treatment of juvenile idiopathic arthritis, and the promise of SLCO1B1‐guided dosing. Polymorphisms to the SLCO1B1 gene influence MTX PK and JIA treatment outcomes. Preclinical studies demonstrate reduced MTX exposure and treatment efficacy with the SLCO1B1*14 allele linked to increased hepatic OATP1B1 ...
Felicia Gooden   +10 more
wiley   +1 more source

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 96-112, January 2026.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

Virus inactivation and skin safety studies using far‐UVC LEDs

open access: yesPhotochemistry and Photobiology, Volume 102, Issue 1, Page 48-56, January/February 2026.
This study uses an LED exposure system with a peak output at 233 nm to examine efficacy for inactivation of human coronavirus as well as potential health hazards for human exposure. Abstract Reducing airborne disease transmission is a public health goal.
David Welch   +6 more
wiley   +1 more source

MicroRNA‐223/NE Signaling Pathway Inhibits Lipopolysaccharide‐Induced Acute Lung Injury by Regulating Neutrophil Extracellular Traps

open access: yesMediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Acute lung injury (ALI) is characterized by significant neutrophil infiltration in the lungs, representing a life‐threatening condition with diverse etiologies. However, the mechanisms regulating neutrophil–alveolar epithelial interactions and the pathophysiological roles of neutrophil infiltration in ALI remain incompletely understood ...
Zhengpeng Zeng   +4 more
wiley   +1 more source

Novel Duck Orthoreovirus Induces Ferroptosis in HD11 Cells by Hijacking Cellular Iron Metabolism and Promoting Iron Accumulation

open access: yesTransboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Novel duck orthoreovirus (NDRV) infection induces severe splenic necrosis in ducks, resulting in a cascade of detrimental consequences, including immunosuppression, secondary infections, and diminished vaccine efficacy. Avian orthoreovirus (ARV) exhibits high tropism for macrophages, with splenic macrophages being identified as the primary target cells
Hongzhi Wang   +6 more
wiley   +1 more source

Bovine Tuberculosis

open access: yesAmerican Journal of Public Health and the Nations Health, 1951
openaire   +3 more sources

Advice on animal and public health risks of insects reared on former foodstuffs as raw material for animal feed

open access: yesFood Risk Assess Europe, Volume 4, Issue 1, January 2026.
Abstract In the coming decades, there is expected to be a sharply increased demand for dietary proteins for humans and animals. As a result, there is an increasing focus on reared insects as a new source of protein. According to the Ministry of Agriculture, Nature and Food Quality (LNV), the use of food chain residual flows such as former foodstuffs as
L.F.F. Kox, D.T.H.M. Sijm
wiley   +1 more source

Biomarkers of cell-mediated immunity to bovine tuberculosis.

open access: yesVeterinary Immunology and Immunopathology, 2019
M. Palmer   +6 more
semanticscholar   +1 more source

Bovine Tuberculosis

open access: yesAmerican Journal of Public Health and the Nations Health, 1937
openaire   +3 more sources

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