Results 131 to 140 of about 828,953 (227)
Summary of SLCO1B1 impact on methotrexate treatment of juvenile idiopathic arthritis, and the promise of SLCO1B1‐guided dosing. Polymorphisms to the SLCO1B1 gene influence MTX PK and JIA treatment outcomes. Preclinical studies demonstrate reduced MTX exposure and treatment efficacy with the SLCO1B1*14 allele linked to increased hepatic OATP1B1 ...
Felicia Gooden +10 more
wiley +1 more source
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley +1 more source
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz +8 more
wiley +1 more source
Virus inactivation and skin safety studies using far‐UVC LEDs
This study uses an LED exposure system with a peak output at 233 nm to examine efficacy for inactivation of human coronavirus as well as potential health hazards for human exposure. Abstract Reducing airborne disease transmission is a public health goal.
David Welch +6 more
wiley +1 more source
Background Acute lung injury (ALI) is characterized by significant neutrophil infiltration in the lungs, representing a life‐threatening condition with diverse etiologies. However, the mechanisms regulating neutrophil–alveolar epithelial interactions and the pathophysiological roles of neutrophil infiltration in ALI remain incompletely understood ...
Zhengpeng Zeng +4 more
wiley +1 more source
Novel duck orthoreovirus (NDRV) infection induces severe splenic necrosis in ducks, resulting in a cascade of detrimental consequences, including immunosuppression, secondary infections, and diminished vaccine efficacy. Avian orthoreovirus (ARV) exhibits high tropism for macrophages, with splenic macrophages being identified as the primary target cells
Hongzhi Wang +6 more
wiley +1 more source
Abstract In the coming decades, there is expected to be a sharply increased demand for dietary proteins for humans and animals. As a result, there is an increasing focus on reared insects as a new source of protein. According to the Ministry of Agriculture, Nature and Food Quality (LNV), the use of food chain residual flows such as former foodstuffs as
L.F.F. Kox, D.T.H.M. Sijm
wiley +1 more source
Biomarkers of cell-mediated immunity to bovine tuberculosis.
M. Palmer +6 more
semanticscholar +1 more source

