Results 181 to 190 of about 127,106 (270)

Pharmacokinetic Model Selection for Personalized Infliximab Dosing in IBD

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Infliximab, a monoclonal antibody used for immune‐mediated diseases, shows high interpatient pharmacokinetic variability. Prolonged exposure increases the risk of adverse effects and costs, making dose personalization essential to balance safety, efficacy, and cost‐effectiveness. Population pharmacokinetic models support individualized dosing,
Sahira Chaiben, Peggy Gandia, Thibaut Jamme, Nicolas Congy, Didier Concordet   +4 more
wiley   +1 more source

Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension: A Comparative Study of Biomarkers and Clinical Indicators

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT A major consequence of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is pulmonary hypertension (PH), which raises morbidity and mortality rates. This study assessed biomarker profiles, clinical characteristics and diagnostic efficacy of important coagulation and inflammatory markers in AECOPD patients who have varying ...
Yingjun Huang, Binbin Qin, Bin Shen, Jiayan Zhu, Qi Zheng, Xingdong Zheng, Jingwei Hu, Yajun Song   +7 more
wiley   +1 more source

Pan-Immune-Inflammatory value and risk of latent tuberculosis infection. [PDF]

Sci Rep
Ye X, Kang X, Zhang H, Wang W.
europepmc   +1 more source

Towards Sustainable Indoor Lighting Design: Ensuring Energy Efficiency, Health and Human Wellbeing—A Review

Sustainable Development, Volume 34, Issue S1, Page 1067-1095, January 2026.
ABSTRACT The design of lighting systems, has, in recent years, transcended the basic function of providing visibility, becoming a key component of promoting the health and well‐being of occupants by integrating biological, psychological, and energy aspects. The growing understanding of the effects of light on the circadian cycle has posed a fundamental
Lara Vélez González, Alejandra Santamaría Melenchón, David Baeza Moyano, Roberto Alonso González‐Lezcano   +3 more
wiley   +1 more source

Integrated multi-omics profiling for risk stratification in Asians with COPD. [PDF]

Respir Res
Meldrum OW, Tiew PY, Xu H, Low DY, Ivan FX, Narayana JK, Jaggi TK, Ching J, Chotirmall SH.   +8 more
europepmc   +1 more source

Acute Reduction in Blood Flow in the Right Coronary Artery After PCI Facilitates Pacemaker‐Induced Ventricular Fibrillation

Annals of Noninvasive Electrocardiology, Volume 31, Issue 1, January 2026.
We present a case involving pacemaker sensing dysfunction caused by acute reduction in blood flow in the right coronary artery. The pacing spikes occurred progressively earlier on the T waves, eventually resulting in R‐on‐T pacing that triggered VF. ABSTRACT Asynchronous pacing itself does not directly lead to the development of malignant ventricular ...
Bo Wu, Yaqin Chen, Jianjun Tang, Jia He
wiley   +1 more source

Differences in clinical profiles and cancer incidence among patients with type 2 diabetes in primary care: Comparison between multidisciplinary and usual management. [PDF]

J Multimorb Comorb
Yau STY, Hung CT, Leung EYM, Lee A, Yeoh EK.   +4 more
europepmc   +1 more source

Pharmacogenetic hSLCO1B1*14‐Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
Summary of SLCO1B1 impact on methotrexate treatment of juvenile idiopathic arthritis, and the promise of SLCO1B1‐guided dosing. Polymorphisms to the SLCO1B1 gene influence MTX PK and JIA treatment outcomes. Preclinical studies demonstrate reduced MTX exposure and treatment efficacy with the SLCO1B1*14 allele linked to increased hepatic OATP1B1 ...
Felicia Gooden, Brennan D. Meier, Griffin D. Shaffer, Kim Gibson, Paul Toren, Nieko C. Punt, Sandhya Subash, Dilip K. Singh, Bhagwat Prasad, Laura B. Ramsey, Zachary L. Taylor   +10 more
wiley   +1 more source

Navigating Diagnostic Dilemmas in Cardiology: A Rare Case Report of Tuberculosis Presenting as a Cardiac Abscess. [PDF]

Clin Case Rep
Bayat F, Jame Bozorgi S, Khani M, Jafari Fesharaki M, Bagheri A, Farahani E.   +5 more
europepmc   +1 more source

S3 Guideline for the treatment of psoriasis vulgaris, adapted from EuroGuiDerm – part 1: Treatment recommendations and monitoring

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 1, Page 122-137, January 2026.
Summary This first part of the updated German S3 guideline on the treatment of psoriasis vulgaris covers the sections on treatment recommendations, treatment goals, and monitoring of therapies. The recommendations are based on the current Cochrane network meta‐analysis, the results of which are also summarized.
Alexander Nast, Andreas Altenburg, Matthias Augustin, Frank Bachmann, Wolf‐Henning Boehncke, Markus Cornberg, Hilte Geerdes‐Fenge, Brit Häcker, Peter Härle, Joachim Klaus, Michaela Köhm, Arno Köllner, Ulrich Mrowietz, Hans‐Michael Ockenfels, Antonia Pennitz, Sandra Philipp, Thomas Richter, Thomas Rosenbach, Tom Schaberg, Martin Schlaeger, Gerhard Schmid‐Ott, Michael Sebastian, Karisa Thölken, Ralph von Kiedrowski, Uwe Willuhn, Christoph Zeyen   +25 more
wiley   +1 more source