Results 51 to 60 of about 41,022 (193)

No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects

International Journal of Cancer, EarlyView.
What's New? Venous thromboembolism (VTE) is common in cancer patients, with direct oral anticoagulants, including rivaroxaban, recommended as first‐line therapy. However, oral anticoagulant use is limited due to the growing use of targeted therapy and concerns about drug‐drug interactions.
Esther M. Hollander, Alessandra I. G. Buma, Jenneke Leentjens, Paddy K. C. Janssen, Michel M. van den Heuvel, David M. Burger, Berber Piet, Rob ter Heine   +7 more
wiley   +1 more source

Primary tubercular liver abscess in an immunocompetent adult: a case report

Journal of Medical Case Reports, 2009
Introduction Isolated primary tubercular abscess is one of the rare forms of extrapulmonary tuberculosis. A greater awareness of this rare clinical entity may help in commencing specific evidence-based therapy quickly and preventing undue morbidity and ...
Baveja CP, Gumma Vidyanidhi, Chaudhary Monica, Jha Himanshu   +3 more
doaj   +1 more source

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

Case report on serohepatic tuberculosis (frosted liver): Clinical presentation, imaging, diagnosis, and management

Radiology Case Reports
Hepatic tuberculosis can manifest in various forms, including parenchymal, serohepatic, tuberculous cholangitis and mixed form. Isolated hepatic tuberculosis, specifically in the form of serohepatic tuberculosis, is very rare.
Prajwal Dahal, MD, Alina Awale, MD, Sabina Parajuli, MBBS   +2 more
doaj   +1 more source

Diagnostic Performance of Comprehensive Point‐of‐Care Ultrasound for Pediatric Tuberculosis in Spain: A Prospective Observational Study

Journal of Clinical Ultrasound, EarlyView.
In children with presumptive tuberculosis, comprehensive point‐of‐care (cPOCUS) identified key thoracic abnormalities with high specificity and excellent inter‐reader reliability. Although diagnostic sensitivity was modest and examinations often incomplete, cPOCUS shows promise as a complementary, radiation‐free imaging tool.
Isabelle Munyangaju, Antoni Noguera‐Julian, Aleix Soler‐Garcia, Antoni Soriano‐Arandes, José Miguel Escudero Fernández, Maria Espiau, Begoña Santiago Garcia, Alicia Hernanz‐Lobo, Ángel M. Lancharro Zapata, Enrique Ladera, Angela Manzanares, Daniel Blazquez, Elisa Aguirre Pascual, Isabelle Thierry‐Chef, Danilo Buonsenso, Xavier Serres‐Créixams, Quique Bassat, Elisa Lopez‐Varela   +17 more
wiley   +1 more source

Detection of Mycobacterium tuberculosis in a patient with suspected cystic echinococcosis: a case report

Journal of Medical Case Reports
Background Tuberculosis is a global health issue affecting millions of people worldwide. While pulmonary tuberculosis is common, hepatic tuberculosis is rare and accounts for less than 1% of cases.
Simon Daller, Julian Frederic Hotz, Moritz Staudacher, Polina Kalinina, Susanna Lang, Fredrik Waneck, Heimo Lagler   +6 more
doaj   +1 more source

Iron Regulation in Elderly Asian Elephants (Elephas maximus) Chronically Infected With Mycobacterium tuberculosis

Frontiers in Veterinary Science, 2020
Restriction of nutrients to pathogens (nutritional immunity) is a critical innate immune response mechanism that operates when pathogens such as Mycobacterium tuberculosis have the potential to evade humoral immunity.
Maja Ruetten, Hanspeter W. Steinmetz, Markus Thiersch, Marja Kik, Lloyd Vaughan, Sandro Altamura, Martina U. Muckenthaler, Martina U. Muckenthaler, Martina U. Muckenthaler, Max Gassmann, Max Gassmann   +10 more
doaj   +1 more source

Potential Biomarkers for Disease Stratification and Prognosis Prediction in Pediatric Asthma: LCN2, sST2 and FGF21

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric asthma is a common chronic airway inflammatory disease, where accurate assessment of disease severity and prognosis prediction is crucial for treatment decisions. Currently, there is a lack of precise and effective biomarkers.
Xu Yang, Hai Wang, Yong‐Zheng Zhang, Yan‐Yan Chen, Xin‐Xin Xing, Yi‐Cheng Ding   +5 more
wiley   +1 more source

Primary hepatic tuberculosis: A rare occurrence [PDF]

Annals of Hepato-Biliary-Pancreatic Surgery, 2019
Primary hepatic tuberculosis is a rare entity and can closely mimic malignancy with respect to clinical presentation and imaging features. We identified five patients at a high volume tertiary care cancer center, whose clinical features and imaging closely mimicked primary liver malignancy or metastases but final histopathology was suggestive of ...
Niyogi, Devayani, Goel, Mahesh, Shinde, Rajesh S, Patkar, Shraddha   +3 more
openaire   +2 more sources

CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine

Med Research, EarlyView.
ABSTRACT Sepsis remains a leading cause of mortality worldwide due to its profound biological heterogeneity. While multi‐omics approaches offer promise for precision medicine, existing datasets often lack longitudinal granularity or comprehensive clinical integration. We present the Chinese Multi‐omics Advances In Sepsis (CMAISE) cohort, a prospective,
Jie Yang, Suibi Yang, Jiajun Cai, Songzan Qian, Shuping Song, Jun Guo, Yang Wang, Jinyan Xing, Bo Zhang, Zhihao Wang, Shengze Wu, Xinhao Jin, Bowen Tan, Dongdong Yang, Yao Yan, Haoran Chen, Changlin Sun, Kang Zou, Yuxin Leng, Jingye Pan, Tianlong Zhang, Yiming Shao, Lina Xian, Hongjun Kang, Zhen Wang, Ruilan Wang, Nan Wang, Lvyin Yan, Kun Cheng, Songqiao Liu, Lin Chen, Caibao Hu, Fuhong Su, Qian Gao, Yi Yang, Zhongheng Zhang, On behalf of Chinese Multi‐omics Advances In Sepsis (CMAISE) Consortium   +36 more
wiley   +1 more source