Results 31 to 40 of about 436,843 (255)

Patterns of ocular inflammation in patients with miliary tuberculosis [version 1; referees: 2 approved]

F1000Research, 2017
Background: Ocular morbidity associated with systemic tuberculosis is common. The clinical picture varies from anterior uveitis, intermediate uveitis and posterior uveitis to even panuveitis.
Salil Mehta
doaj   +1 more source

Local ischemia and increased expression of vascular endothelial growth factor following ocular dissemination of Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2011
The pathogenesis of intraocular tuberculosis remains poorly understood partly due to the lack of adequate animal models that accurately simulate human disease.
Seema M Thayil, Thomas A Albini, Hossein Nazari, Andrew A Moshfeghi, Jean-Marie A Parel, Narsing A Rao, Petros C Karakousis   +6 more
doaj   +1 more source

Relationship between severity of HIV infection and ocular pathology in patients with pulmonary tuberculosis

Journal of Ophthalmology, 2018
Background: Pulmonary tuberculosis most commonly develops and often becomes generalized among HIV-infected patients. HIV-positive individuals present extra-pulmonary forms of tuberculosis twice as often as HIV-negative individuals.
I.N.Voronova, V.M. Khokkanen, S.I. Sanaeva, M.V. Zhemkova   +3 more
doaj   +1 more source

Choroidal granuloma resolution with tuberculosis treatment

American Journal of Ophthalmology Case Reports, 2020
Purpose: To report a case of presumed ocular tuberculosis, successfully treated with anti-tubercular therapy alone. Observations: Resolution of a presumed tubercular choroidal granuloma occurred after initiation of 4-drug anti-tubercular therapy, without
LeAnne Young, Mehmet Yakin, H. Nida Sen
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Ocular manifestation of systemic tuberculosis in children at tertiary pediatric hospital in North India

Kerala Journal of Ophthalmology
Background: Tubnerculosis is Characterised by the presence of granuloma formation. The mode of spread of pulmonary tuberculosis is via airborne aerosol. This bacteria enters the lungs and leads to latent infection in susceptible hosts.
Meenakshi Wadhwani, Amit Kumar, Dhulika Dhingra, Hem Sati   +3 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Diagnóstico de tuberculose ocular

, 2016
A tuberculose ocular continua sendo um diagnóstico clínico presuntivo, pois os testes padrão-ouro para diagnosticar a tuberculose ocular geralmente não são úteis: as culturas de Mycobacterium tuberculosis requerem semanas para serem processadas em meio ...
Marcus Ang, Massimo Accorinti, Daniel Vítor de Vasconcelos Santos, Amod Gupta, Aman Sharma, Soon-Phaik Chee, Kusum Sharma, Narsing Rao   +7 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source