Results 171 to 180 of about 206,114 (317)

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

open access: yesAllergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti   +18 more
wiley   +1 more source

Containing Histories Past and Present: Making Samples in the “Huntington Collection” (1893–1921)

open access: yesAmerican Anthropologist, EarlyView.
ABSTRACT The Huntington Anatomical Collection (1893–1921) includes the skeletal remains of immigrants, migrants, and lifelong New York City residents. The collection's formation was coeval with the formalization of physical anthropology, and the collection was made to serve research aims centered on race and origin.
Alanna L. Warner‐Smith
wiley   +1 more source

Cigarette smoke and human pulmonary immune responses to mycobacteria

open access: yes, 2011
Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells ...
Van Zyl-Smit, Richard Nellis
core  

Infection control in the brain and the eye

open access: yesActa Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester   +2 more
wiley   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Research on the drug delivery of inhaled corticosteroids and combination medications via valved holding chambers (VHCs) with children's breathing patterns is limited. We aimed to evaluate the in vitro performance of commercially available VHCs without facemasks under preschooler breathing conditions, focusing on total delivered dose and ...
Laura Ojanperä   +2 more
wiley   +1 more source

Health Research Funders and Justice: Obligations to Coordinate and Counterbalance

open access: yesBioethics, EarlyView.
ABSTRACT Government health research funders are frequently criticized on the grounds that their distribution of resources fails to reflect a population's disease burden. These critiques do not take into account what other research funders are doing. In this paper, I argue that this is a mistake.
Joseph Millum
wiley   +1 more source

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