Results 51 to 60 of about 1,153,912 (357)

IMMUNOLOGY OF TUBERCULOSIS [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2014
MTB ranks as the first worldwide pathogen latently infecting one third of the population and the second leading cause of death from a single infectious agent, after the human immunodeficiency virus (HIV). The development of vigorous and apparently appropriate immune response upon infection with M.tuberculosis in humans and experimental animals conflict
Bozzano F, Marras F, DE MARIA, ANDREA
openaire   +4 more sources

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Immunology of Mycobacterium tuberculosis Infections

Microbiology spectrum, 2019
Tuberculosis (TB) is a serious global public health challenge that results in significant morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium tuberculosis (M.
J. K. Sia, Jyothi Rengarajan
semanticscholar   +1 more source

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Addressing the burden and detection gap of latent tuberculosis infection in schoolchildren and adolescents in China: a cross-sectional study

BMC Infectious Diseases
Background The latent tuberculosis infection (LTBI) burden is still unclear in schoolchildren and adolescents in China. Previous study and daily surveillance data indicate a LTBI detection gap.
Bo Wu, Ya Yu, Chengguo Wu, Yaling Shi, Ying Liu, Jin Yin, Qian Su, Zhengyu Zhang, Xueyong Huang, Mei Wang, Yan Pang, Jiyuan Zhong, Jun Fan   +12 more
doaj   +1 more source

Drug susceptibility of low growing non-tuberculous mycobacteria

Туберкулез и болезни лёгких, 2016
In order to investigate the spectrum of drug susceptibility of slowly growing of non-tuberculous mycobacteria and define minimum inhibiting concentrations (MIC) regarding the drug panel including anti-tuberculosis drugs and antimicrobial agents of wide ...
S. N. Аndreevskaya, E. E. Larionova, T. G. Smirnova, I. Yu. Аndrievskaya, E. A. Kiseleva, L. N. Chernousova   +5 more
doaj   +1 more source

TUBERCULOSIS OF THE BLADDER

Annals of Surgery, 1907
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Walker, George, Baltimore,
openaire   +8 more sources

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Phase 2b placebo-controlled trial of M72/AS01E candidate vaccine to prevent active tuberculosis in adults

New England Journal of Medicine, 2018
BACKGROUND A vaccine to interrupt the transmission of tuberculosis is needed. METHODS We conducted a randomized, double‐blind, placebo‐controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South Africa, and Zambia.
Olivier Van Der Meeren, M. Hatherill, V. Nduba, R. Wilkinson, M. Muyoyeta, Elana van Brakel, H. Ayles, G. Henostroza, F. Thienemann, T. Scriba, A. Diacon, G. Blatner, M. Demoitié, M. Tameris, M. Malahleha, J. Innes, Elizabeth Hellström, N. Martinson, T. Singh, E. J. Akité, Aisha Khatoon Azam, A. Bollaerts, A. Ginsberg, T. Evans, P. Gillard, D. Tait   +25 more
semanticscholar   +1 more source

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source