Results 41 to 50 of about 107,669 (285)

Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

mSphere
It is unclear whether human progression to active tuberculosis disease (TB) risk signatures are viable endpoint criteria for evaluations of treatments in development.
Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler   +7 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Molecular Therapy: Nucleic Acids, 2022
Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the ...
Irene Pérez, Elena Campos-Pardos, Caridad Díaz, Santiago Uranga, Fadel Sayes, Francisca Vicente, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio   +9 more
doaj   +1 more source

Community perceptions of a malaria vaccine in the Kintampo districts of Ghana. [PDF]

, 2013
BACKGROUND: Malaria remains the leading cause of morbidity and mortality in sub-Saharan Africa despite tools currently available for its control. Making malaria vaccine available for routine use will be a major hallmark, but its acceptance by community ...
A Bingham, A Dodoo, A Launiala, A Olotu, AK Rowe, AS Jegede, C Wongsrichanalai, CA Baume, CA de Quadros, Dan-Bright S Dzorgbo, DB Dery, DI Ojakaa, E Klinkenberg, F Nuwaha, FN Binka, G GSS, Kojo A Senah, KP Asante, Kwaku P Asante, Lawrence G Febir, PW Chung, RW Snow, S Owusu-Agyei, S Owusu-Agyei, S Owusu-Agyei, Seth Owusu-Agyei, ST Agnandji, ST Agnandji, TE Nkya, Timothy S Letsa, WHO   +30 more
core   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Therapeutic Vaccines for Tuberculosis: An Overview

Frontiers in Immunology, 2022
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world’s deadliest bacterial infection, resulting in more than 1.4 million deaths annually.
Rania Bouzeyen, Babak Javid
doaj   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall, A Cruz, A Glatman-Freedman, AM Cooper, AR Martineau, B Nandi, C Diveu, C Keller, CE Sutton, CG Feng, Christopher M. Sassetti, CJ Thalhofer, CY Hu, D Kitamura, DB Rawool, DJ Cua, DV Jovanovic, E Lockhart, E Marino, E Roy, E Torrado, EB Eruslanov, FE Lund, FL Ribeiro-Gomes, J Hinchey, J Pedrosa, Jiayong Xu, JL Flynn, JM Daley, Joanne L. Flynn, John Chan, JS Thorson, JU Igietseme, K Dunussi-Joannopoulos, K Hamel, KA Sweeney, Kyri Dunussi-Joannopoulos, L Desvignes, L Li, Lee Kozakiewicz, LJ Brady, M Cella, M Laan, M Zhang, MC Tsai, ML Michel, NK Damle, P Miossec, P Seiler, P Ye, PJ Maglione, PJ Maglione, PJ Maglione, PR Hamann, PS Redford, Qinglin Ou, R Appelberg, R Blomgran, R Gopal, RJ North, SA Fulton, SA Khader, ST Passos, Steven A. Porcelli, T Eddens, T Hamilton, T Korn, T Matsushita, TK Kondratieva, W Ouyang, William R. Jacobs, X Zhang, Y Ito, Yanhua Wang, Yong Chen   +74 more
core   +3 more sources

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genome-wide RNA Interference Screening

Genomics, Proteomics & Bioinformatics, 2022
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), which is still the leading cause of mortality from a single infectious disease worldwide.
Khaista Rahman, Muhammad Jamal, Xi Chen, Wei Zhou, Bin Yang, Yanyan Zou, Weize Xu, Yingying Lei, Chengchao Wu, Xiaojian Cao, Rohit Tyagi, Muhammad Ahsan Naeem, Da Lin, Zeshan Habib, Nan Peng, Zhen F. Fu, Gang Cao   +16 more
doaj   +1 more source

Novel particulate vaccine candidates recombinantly produced by pathogenic and nonpathogenic bacterial hosts : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand. [PDF]

, 2017
Polyhydroxyalkanoates (PHAs) are biopolyesters synthesized as small spherical cytoplasmic inclusion bodies by a range of bacteria. Recently, PHA beads have been investigated for use as a vaccine delivery platform by using engineered heterologous ...
Lee, Jason Wong
core