Results 71 to 80 of about 107,669 (285)
TB vaccine development: monitoring international patent filings to anticipate access challenges
Frontiers in Public HealthIntroductionEvery year, an estimated 10 million new cases of tuberculosis (TB) are diagnosed, and 1.6 million deaths occur worldwide due to this disease.
María Florencia Pignataro +6 more
doaj +1 more source
TRIPS and knowledge diffusion from low‐ and middle‐income countries
Strategic Management Journal, EarlyView.Abstract Research Summary We examine a significant yet underappreciated effect of IPR implementation: the dissemination after TRIPS implementation of established scientific knowledge from low‐ and middle‐income countries (LMICs) into the global scientific system of pharmaceutical development.
Michael Blomfield +2 more
wiley +1 more source
Small, EarlyView.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Tuberculosis vaccine strain _Mycobacterium bovis_ BCG Russia is a natural _recA_ mutant [PDF]
, 2008 The current tuberculosis vaccine is a live vaccine derived from _Mycobacterium bovis_ and attenuated by serial _in vitro_ passaging. All vaccine substrains in use stem from one source, strain Bacille Calmette-Guérin.
Erik C. Boettger +2 more
core +1 more source
Allergy, EarlyView.ABSTRACT Background Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated an EAACI‐endorsed update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (ARIA 2024 ...
Bernardo Sousa‐Pinto +252 more
wiley +1 more source
100 Years of Vaccination against Tuberculosis – Lessons Learnt and Prospects
Туберкулез и болезни лёгкихThe article presents a literature review dedicated to the 100th anniversary of introduction of the BCG vaccine against tuberculosis; it analyzes of 83 publications by Russian and foreign authors.
E. M. Bogorodskaya +2 more
doaj +1 more source
PRODUCTION OF MYCOBACTERIUM TUBERCULOSIS TB10.4 RECOMBINANT PROTEIN IN ESCHERICHIA COLI
Инфекция и иммунитет, 2016 Nowadays tuberculosis is considered one of the most dangerous infectious diseases occurring everywhere, and it remains a cause of death of millions of people around the world.
I. V. Dukhovlinov +6 more
doaj +1 more source
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]
, 2005 Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Buxton, RS +8 more
core +2 more sources
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations
Vaccines, 2014 Novel efficient vaccines are needed to control tuberculosis (TB), a major cause of morbidity and mortality worldwide. Several TB vaccine candidates are currently in clinical and preclinical development.
Amaya Leunda +5 more
doaj +1 more source