Results 1 to 10 of about 178,050 (257)

The Epidemiology of Meningitis among Adults in a South African Province with a High HIV Prevalence, 2009-2012. [PDF]

PLoS ONE, 2016
INTRODUCTION:Meningitis is a major cause of mortality in southern Africa. We aimed to describe the aetiologies and frequencies of laboratory-confirmed fungal and bacterial meningitis among adults in a South African province with an 11% HIV prevalence ...
Erika Britz, Olga Perovic, Claire von Mollendorf, Anne von Gottberg, Samantha Iyaloo, Vanessa Quan, Verushka Chetty, Charlotte Sriruttan, Nazir A Ismail, Ananta Nanoo, Alfred Musekiwa, Carl Reddy, Karien Viljoen, Cheryl Cohen, Nelesh P Govender   +14 more
doaj   +1 more source

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Nature Communications, 2019
Tuberculous meningitis (TBM) is the most severe form of TB with high rates of mortality and morbidity. Here we conduct RNA-sequencing on whole blood as well as on ventricular and lumbar cerebrospinal fluid (CSF) of pediatric patients treated for TBM ...
U. Rohlwink, A. Figaji, K. Wilkinson, S. Horswell, A. Sesay, A. Deffur, N. Enslin, R. Solomons, R. van Toorn, B. Eley, M. Levin, R. Wilkinson, Rachel P. J. Lai   +12 more
semanticscholar   +1 more source

Bacterial meningitis and tuberculous meningitis. [PDF]

BMJ, 1973
Despite the wide range of antimicrobial drugs available to day the mortality and morbidity from bacterial meningitis is disappointingly high. This disappointment is all the more poignant when one appreciates that some 75% of pyogenic meningitis in Britain results from infection by one of three organisms?namely, Neisseria meningitidis, Streptococcus ...
openaire   +3 more sources

Incidence of tuberculous meningitis in the State of Santa Catarina, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2014
Introduction The aim of this study was to estimate the incidence of tuberculous meningitis in the State of Santa Catarina (SC), Brazil, during the period from 2001 to 2010.
Cíntia Helena de Souza, Ayaka Yamane, Jeison Cleiton Pandini, Luciane Bisognin Ceretta, Fabiane Ferraz, Glauco Duarte da Luz, Priscyla Waleska Simões   +6 more
doaj   +1 more source

Tuberculous meningitis with good outcome following appropriate timing of ventriculoperitoneal shunting for hydrocephalus

Acute Medicine & Surgery, 2022
Background Tuberculous meningitis is often associated with hydrocephalus. However, the appropriate timing for shunt placement to treat hydrocephalus remains controversial.
Junzo Nakao, Keishi Fujita, Kazuhiro Ishii, Yoshimitsu Akutsu, Takuma Hara, Takao Kamezaki, Eiichi Ishikawa   +6 more
doaj   +1 more source

A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

eLife, 2018
Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory,
N. Mai, N. Dobbs, N. Phu, R. Colas, Le T P Thao, Nguyen T T Thuong, Ho D T Nghia, N. H. Hanh, N. T. Hang, A. D. Heemskerk, J. Day, Lucy Ly, Do D A Thu, L. Merson, E. Kestelyn, M. Wolbers, R. Geskus, D. Summers, N. V. Chau, Jesmond Dalli, G. Thwaites   +20 more
semanticscholar   +1 more source

A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Nucleic Acid Amplification Tests for Tuberculous Meningitis

Journal of Clinical Microbiology, 2019
The diagnosis of tuberculous meningitis (TBM) is difficult and poses a significant challenge to physicians worldwide. Recently, nucleic acid amplification (NAA) tests have shown promise for the diagnosis of TBM, although their performance has been ...
A. Pormohammad, M. Nasiri, Timothy D McHugh, S. Riahi, N. Bahr   +4 more
semanticscholar   +1 more source

Evaluation of Geno Type MTBDRplus Line Probe Assay for Early Detection of Drug Resistance in Tuberculous Meningitis Patients in India

Journal of Global Infectious Diseases, 2015
Background: Molecular methods which allow for rapid and reliable detection of drug resistance have yet not been sufficiently evaluated for timely management of patients with tuberculous meningitis.
Renu Gupta, Rajeev Thakur, Prerna Gupta, Nupur Jalan, Suman Kushwaha, Meena Gupta, Piyush Gupta, Amitesh Aggarwal, Vikas Manchanda   +8 more
doaj   +1 more source

Model-Based Meta-analysis of Rifampicin Exposure and Mortality in Indonesian Tuberculous Meningitis Trials

Clinical Infectious Diseases, 2019
Background Intensified antimicrobial treatment with higher rifampicin doses may improve outcome of tuberculous meningitis, but the desirable exposure and necessary dose are unknown.
E. Svensson, S. Dian, L. T. Te Brake, A. Ganiem, V. Yunivita, A. van Laarhoven, R. van Crevel, R. Ruslami, R. Aarnoutse   +8 more
semanticscholar   +1 more source

Tuberculous meningitis in children: Clinical management & outcome

The Indian journal of medical research, 2019
Although the occurrence of tuberculous meningitis (TBM) in children is relatively rare, but it is associated with higher rates of mortality and severe morbidity.
M. Natrajan, B. Daniel, GAngeline Grace
semanticscholar   +1 more source