Results 1 to 10 of about 193,732 (278)

Defeating Paediatric Tuberculous Meningitis: Applying the WHO “Defeating Meningitis by 2030: Global Roadmap” [PDF]

Microorganisms, 2021
Children affected by tuberculous meningitis (TBM), as well as their families, have needs that lie at the intersections between the tuberculosis and meningitis clinical, research, and policy spheres.
Robindra Basu Roy, Sabrina Bakeera‐Kitaka, Chishala Chabala, Diana M. Gibb, Julie Huynh, Hilda Mujuru, Naveen Sankhyan, James A. Seddon, Suvasini Sharma, Varinder Singh, Eric Wobudeya, Suzanne T. Anderson   +11 more
openalex   +2 more sources

Tuberculous meningitis [PDF]

Clinical Case Reports, 2023
Tuberculous meningitis is possibly complicated with multiple cerebral infarctions and basal meningitis, and the mortality and neurological prognosis is reportedly poor.
Shinnosuke Fukushima, Kazuki Ocho, Koji Fujita, Hideharu Hagiya, Fumio Otsuka   +4 more
doaj   +2 more sources

Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability

Pathogens, 2021
Tuberculous meningitis disproportionately affects young children. As the most devastating form of tuberculosis, it is associated with unacceptably high rates of mortality and morbidity even if treated.
Julie Huynh, Yara-Natalie Abo, Karen du Preez, Regan Solomons, Kelly E Dooley, James A Seddon   +5 more
doaj   +2 more sources

The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes [PDF]

Wellcome Open Research, 2019
Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial pressure frequently result, leading to extensive brain injury and neurodisability ...
James A. Seddon, Lillian Tugume, Regan Solomons, Kameshwar Prasad, Nathan C. Bahr   +4 more
openalex   +2 more sources

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study. [PDF]

Lancet. Infectious Diseases (Print), 2017
BACKGROUND: WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about 50-70% and culture sensitivity of about 60%.
ASTRO-CM Trial Team, Bahr, Nathan C, Bangdiwala, Ananta S, Boulware, David R, Bridge, Sarah C, Byamukama, Adolf, Bystrom, Philip V, Cresswell, Fiona V, Denkinger, Claudia M, Evans, Emily E, Meya, David B, Muzoora, Conrad, Nuwagira, Edwin   +12 more
core   +2 more sources

Orientia tsutsugamushi meningitis in a patient with tuberculous meningitis complications—a Case Report [PDF]

Frontiers in Medicine
Scrub typhus (ST) is caused by infection with Orientia tsutsugamushi, transmitted through chigger mite bites, resulting in a febrile disease. Clinical manifestations are complex and may be combined with other microbial infections. This report describes a
Miao Tan, Hao Zou, MaiQing Yang, Anchun Liu   +3 more
doaj   +2 more sources

Evaluation of Cerebrospinal fluid adenosine deaminase activity as a complimentary tool in the early diagnosis of tuberculous meningitis in children

Journal of College of Medical Sciences-Nepal, 2012
The diagnosis of tuberculous meningitis cannot be made or excluded on the basis of clinical findings. Definite laboratory diagnosis is cumbersome and time consuming.
A Pan, A Biswas, A Chaterjee, R Kumar
doaj   +3 more sources

Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

New England Journal of Medicine, 2023
Background Adjunctive corticosteroids are widely used to treat HIV-associated tuberculous meningitis despite limited data supporting their safety and efficacy. Methods We conducted a randomized double-blind placebo-controlled trial in HIV-positive adults
Joseph Donovan, N. D. Bang, Darma Imran, Ho D T Nghia, Erlina Burhan, Dau T T Huong, Nguyen T T Hiep, L. H. Ngoc, D. V. Thanh, Nguyen T Thanh, Anna L S Wardhani, Kartika Maharani, C. P. Gasmara, Nguyen H H Hanh, P. Oanh, R. Estiasari, Do D A Thu, Ardiana Kusumaningrum, Le T Dung, D. C. Giang, Dang T M Ha, N. H. Lân, Nguyen V V Chau, N. T. M. Nguyệt, R. Geskus, Nguyen T T Thuong, E. Kestelyn, R. Hamers, N. Phu, Guy E. Thwaites   +29 more
semanticscholar   +1 more source

Predominance of Escherichia-Shigella in Gut Microbiome and Its Potential Correlation with Elevated Level of Plasma Tumor Necrosis Factor Alpha in Patients with Tuberculous Meningitis

Microbiology spectrum, 2022
As the most severe form of tuberculosis, the pathogenesis of tuberculous meningitis (TBM) is still unclear. Gut microbiota dysbiosis plays an important role in a variety of central nervous system diseases.
Shanshan Li, Jidong Guo, Rongmei Liu, Fuzhen Zhang, Shu’an Wen, Yi Liu, Weicong Ren, Xu-xia Zhang, Y. Shang, M. Gao, Jie Lu, Y. Pang   +11 more
semanticscholar   +1 more source

High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis

Journal of Clinical Investigation, 2022
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality.
Camilo A. Ruiz-Bedoya, F. Mota, E. Tucker, Farina J. Mahmud, Maria I. Reyes-Mantilla, Clara Erice, Melissa Bahr, Kelly Flavahan, Patricia de Jesus, John Kim, C. Foss, C. Peloquin, D. Hammoud, A. Ordonez, C. Pardo, Sanjay K. Jain   +15 more
semanticscholar   +1 more source