The pathogenesis of tuberculous meningitis [PDF]
Abstract Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb)
Anthony Figaji+6 more
openaire +3 more sources
Tuberculous Meningitis Presented with Bilateral Sensorineural Hearing Loss: Acute Deafness
Tuberculous meningitis is the most severe manifestation of extrapulmonary tuberculosis with a high mortality and morbidity rates. It is usually presented with headache, fever, consciousness disturbances and convulsions. Eigth cranial nerve involvement is
Kürşad Çetin Akpınar+2 more
doaj +2 more sources
Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer
Introduction: Tuberculous meningitis is rare but one of the most severe forms of tuberculosis infection. Case Report: A 78-year-old woman was diagnosed with advanced gastric cancer with multiple lymph node metastases.
Hiroshi Matsumoto+6 more
doaj +1 more source
Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis [PDF]
We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors.
Figaji, Anthony A+4 more
core +2 more sources
Circulating Growth Differentiation Factor 15 (GDF15) in Paediatric Disease: A Systematic Review
ABSTRACT Background Growth Differentiation Factor 15 (GDF15), a nonspecific inflammatory marker and member of the TGF‐β superfamily, has a well‐established role in both inflammation and metabolic modulation, but lacks a comprehensive paediatric literature review.
David W. Kronenberger+3 more
wiley +1 more source
Features of a Course of General Tuberculosis in Adolescents
The feature of a course of tuberculosis in adolescence is the tendency to progression, necrotic reactions. The most severe outcome of general specific process is the development of meningitis, which can often be its end stage.
O.M. Raznatovska+4 more
doaj +1 more source
A PROSPECTIVE STUDY ON EVALUATION OF DIAGNOSTIC PERFORMANCE OF GENEXPERT MTB IN CSF FOR EARLY DIAGNOSIS OF TUBERCULAR MENINGITIS IN A TERTIARY CARE HOSPITAL ODISHA. [PDF]
Aim The study aims to establish the diagnostic accuracy of GeneXpert MTB/RIF in CSF for early diagnosis of tubercular meningitis and to compare the efficacy of CSF GeneXpert MTB/RIF with CSF culture for mycobacterium.
Behera, Debasis+5 more
core +2 more sources
In this case series, we assess the effectiveness and anatomical advantages of the lateral transorbital approach for complex skull base repairs in the lateral recess of a pneumatized sphenoid sinus and compare it to standard transnasal methods. We conclude that the lateral transorbital approach enhances visualization, reduces nerve injury risk, and ...
Darlene Lubbe+2 more
wiley +1 more source
Neuroradiological manifestations of tuberculous meningitis [PDF]
Tuberculous meningitis (TBM) represents the most severe form of extra pulmonarytuberculosis (1).The early and exact diagnosis of TBM is important but difficult due to time consuming definitive microbiological procedures (2).Neuroimaging is an important ...
Badshah, Mazhar+3 more
core +1 more source
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]
BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S+6 more
core +1 more source