The pathogenesis of tuberculous meningitis [PDF]
Abstract Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb)
Angharad Grace, Davis +4 more
openaire +2 more sources
Abstract Background To identify early diagnostic clues, we analysed cerebrospinal fluid and serum biomarkers in patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) and compared biomarker trends with those in patients with viral meningoencephalitis, tuberculous meningoencephalitis, and anti‐N‐methyl‐D‐aspartate receptor ...
Siruo Guo +3 more
wiley +1 more source
The Epidemiology of Meningitis among Adults in a South African Province with a High HIV Prevalence, 2009-2012. [PDF]
INTRODUCTION:Meningitis is a major cause of mortality in southern Africa. We aimed to describe the aetiologies and frequencies of laboratory-confirmed fungal and bacterial meningitis among adults in a South African province with an 11% HIV prevalence ...
Erika Britz +14 more
doaj +1 more source
Murine cytomegalovirus genomic material in marrow cells; relation to altered leukocyte counts during sublethal infection of mice [PDF]
To investigate infection of hematopoietic cells by murine cytomegalovirus (MCMV), we used in situ hybridization to detect MCMV genomic material in marrow cells during sublethal infection of three-week-old mice.
Bale, J. F. +4 more
core +1 more source
Coronal reconstruction post contrast thoraco‐abdominal CT of a 9 years old boy taken December, 2023. This shows 1.45 by 3.9 cms hypodense collection having rim enhancement in the right anterio‐inferior sub‐phrenic space suggestive of abscess. ABSTRACT Diagnosing extrapulmonary and drug‐resistant tuberculosis in children is challenging.
Animaw Lingerew +4 more
wiley +1 more source
Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis [PDF]
BACKGROUND: Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are
Abubakar +42 more
core +2 more sources
Germ Panic and Chalice Hygiene in the Church of England, c.1895–1930
The late‐Victorian medical revolution in bacteriology, and growing public awareness of hygienic standards and the danger of disease infection from germs, created alarm about the traditional Christian practice of drinking from a common cup at Holy Communion.
Andrew Atherstone
wiley +1 more source
Post Penicillin Antibiotics: From acceptance to resistance? [PDF]
Edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, in London, on 12 May 1998. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000.
Reynolds, LA, Tansey, EM
core
Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis [PDF]
Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. it is more common in human immunodeficiency virus (HIV)-positive patients.
Caws, Maxine +14 more
core +1 more source
Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments
ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia +3 more
wiley +1 more source

