Results 71 to 80 of about 358,265 (351)

Psychiatric Impact of Tuberous Sclerosis Complex and Utilization of Mental Health Treatment [PDF]

, 2018
Tuberous sclerosis complex (TSC) is a multi-system, neurocutaneous disorder with neuropsychiatric features known as TSC-associated neuropsychiatric disorders (TAND).
Mowrey, Kate
core   +1 more source

Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. [PDF]

, 2018
Diffuse cutaneous mastocytosis (DCM) is a rare but potentially fatal condition when diagnosis and targeted treatments are delayed. This case illustrates the life-threatening complications in DCM and reviews the currently available treatments.
Akin, Alvarez-Twose, Bankova, Bodemer, Brockow, Brockow, Caughey, Chan, Edwards, Escribano, Escribano, Flageul, Fried, Galli, Garg, Hannaford, Hartmann, Has, Heide, Huang, Lange, Melo, Murphy, Orkin, Polk, Poterack, Prieto-García, Smith, Tolar, Valent, Wolff, Zhang, Álvarez-Twose   +32 more
core   +1 more source

Epileptogenicity in tuberous sclerosis complex: A stereoelectroencephalographic study

Epilepsia, 2019
In tuberous sclerosis complex (TSC)‐associated drug‐resistant epilepsy, the optimal invasive electroencephalographic (EEG) and operative approach remains unclear. We examined the role of stereo‐EEG in TSC and used stereo‐EEG data to investigate tuber and
A. Neal, K. Ostrowsky‐Coste, Julien Jung, S. Lagarde, L. Maillard, P. Kahane, R. Touraine, H. Catenoix, A. Montavont, J. Isnard, A. Arzimanoglou, F. Bartolomei, M. Guenot, S. Rheims   +13 more
semanticscholar   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Segmental collagenoma in tuberous sclerosis – Think beyond the skin: A rare case report

Indian Journal of Dermatology, 2023
Collagenomas are connective tissue nevi characterized by an imbalance in the distribution and amount of collagen in the extracellular matrix. Shagreen patch, a collagenoma of tuberous sclerosis, is a classical finding in this genodermatosis (Tuberous ...
Ashok Kumar Nagarajan, Krishnaswamy Manoharan, Shreya Moozhiyil   +2 more
doaj   +1 more source

TuberOus SClerosis registry to increase disease Awareness (TOSCA) – baseline data on 2093 patients

Orphanet Journal of Rare Diseases, 2017
BackgroundTuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder. Many gaps remain in the understanding of TSC because of the complexity in clinical presentation.
J. Kingswood, G. B. d'Augères, E. Belousova, J. Ferreira, T. Carter, R. Castellana, V. Cottin, P. Curatolo, M. Dahlin, P. D. de Vries, M. Feucht, C. Fladrowski, G. Gislimberti, C. Hertzberg, S. Jóźwiak, J. Lawson, A. Macaya, R. Nabbout, F. O'callaghan, M. Benedik, J. Qin, R. Marques, Valentin Sander, M. Sauter, Yukitoshi Takahashi, R. Touraine, S. Youroukos, B. Zonnenberg, A. Jansen   +28 more
semanticscholar   +1 more source

Lesions Associated With Autism Symptoms Map to a Cerebellar Brain Network in Tuberous Sclerosis Complex

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Autism spectrum disorder (ASD) affects 1 in 36 individuals in the United States and is characterized by impaired social communication and restrictive/repetitive behaviors. Individuals with tuberous sclerosis complex (TSC) have a high incidence of ASD (40%) and exhibit congenital brain lesions (tubers), offering a unique lesion‐based ...
Wendy Xiao Herman, Gillian N. Miller, Mustafa Sahin, Jurriaan M. Peters, Simon K. Warfield, Darcy A. Krueger, E. Martina Bebin, Hope Northrup, Joyce Y. Wu, Michael D. Fox, Alexander L. Cohen   +10 more
wiley   +1 more source

The effect of pregnancy on renal angiomyolipoma; a world of knowledge to gain, specifically in women with TSC

BMC Nephrology
Background Women are counseled preconceptionally about the potential risks of rAML progression and chance of complications during and due to pregnancy. However, a systematic search investigating the evidence on which this advice is based does not exist ...
Marlou W. Kluiving, Evelien F. H. I. Peeters, Titia A. Lely, Niek van Oorschot, Wendela L. de Ranitz-Greven   +4 more
doaj   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo, Donna A. Volpe, Anik Chaturbedi, Aanchal Shah, Ashok Krishna, Paula L Hyland, Giri Vegesna, Cheng‐Hui Hsiao, Ryan De Palma, Melanie Fein, Rodney Rouse, Jeffry Florian   +11 more
wiley   +1 more source

mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis. [PDF]

, 2016
Several preclinical and some clinical studies have revealed that the mammalian target of rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy syndromes.
Citraro, R, Constanti, A, Leo, A, Russo, E, Sarro, G   +4 more
core   +1 more source