Results 141 to 150 of about 5,402,382 (253)

Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

Cancer Science, EarlyView.
Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang   +9 more
wiley   +1 more source

Out of the Ordinary, but Not Out of the Question: Atypia in Pancreatic Lesions Is Not Always Carcinoma

Cytopathology, EarlyView.
An incidental pancreatic lesion in a 69‐year‐old woman was sampled by EUS‐guided fine‐needle biopsy. Integrated cytopathological and histopathological evaluation with immunochemical staining supported organ‐preserving surgery. ABSTRACT Pancreatic perivascular epithelioid cell tumours (PEComas) are exceptionally rare mesenchymal neoplasms.
Maja Kebe Radulovic, Branislava Rankovic, Ajda Toni, Margareta Zlajpah, Darko Siuka   +4 more
wiley   +1 more source

Descrição atualizada da paralisia cerebral

Developmental Medicine &Child Neurology, EarlyView.
Resumo A paralisia cerebral (PC) é um termo descritivo amplamente utilizado para um espectro de deficiências motoras causadas por lesão ou malformação cerebral não progressiva ocorrida durante as fases iniciais do desenvolvimento. Avanços recentes nas áreas da genética, de pesquisa em inflamação e em neurofisiologia têm refinado a compreensão ...
Bernard Dan, Peter Rosenbaum, Lucinda Carr, Martin Gough, John Coughlan, Nonyelum Nweke   +5 more
wiley   +1 more source

Clinical features and genetic analysis of tuberous sclerosis pedigrees

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective In order to understand tuberous sclerosis complex better, the clinical manifestation, imaging characteristics, and genetic characteristics of tuberous sclerosis complex from 3 pedigrees were investigated.
Ya⁃qin LI, Ji⁃qing CAO, Juan YANG, Bao⁃feng ZHANG, Shan⁃wei FENG, Yan⁃yun WANG, Yao ZHANG, Fei CHEN, Jie KONG, Min⁃ying ZHENG, Xu ZHANG, Cheng ZHANG   +11 more
doaj  

Factors Associated With Challenging Behaviour in People With Severe‐Profound Intellectual Disabilities: A Systematic Review

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Individuals with severe to profound intellectual disability (ID) exhibit high support needs and significant communication impairments and may present with challenging behaviours such as aggression, self‐injury and stereotypies. These behaviours can cause distress, hinder healthcare access and delivery and impair quality of life for ...
I. D. C. van Balkom, J. Cooke, A. G. de Cuba, E. Burkitt‐Wright, C. Gaasterland, M. Burdeus‐Olavarrieta   +5 more
wiley   +1 more source

Operative Management of Phakomatosis Pigmentokeratotica Sequelae: Surgical Techniques and Procedural Pearls

Pediatric Dermatology, EarlyView.
ABSTRACT Phakomatosis pigmentokeratotica (PPK) is a rare variant of epidermal nevus syndrome, classically characterized by the coexistence of nevus sebaceus and nevus spilus. Secondary neoplasms arising within nevus sebaceus, including syringocystadenoma papilliferum (SPAP), can cause persistent irritation, discomfort, and bleeding that negatively ...
Helen Chen, Brooke Walterscheid, Michelle Tarbox, Alba Posligua   +3 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Building a precision therapeutics program at a tertiary care children's hospital

Pediatric Investigation, EarlyView.
Luke Hamilton, Heidi Trinkman, Diana Carrasco, Kaitlin Smith, Kelly Vallance, Alejandra Dominguez, Danielle Miller, Megan Gibbs, Anish Ray   +8 more
wiley   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2454-2463, November 2026.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source