Results 61 to 70 of about 23,821 (165)

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation–mediated 14-3-3 binding

Journal of Biological Chemistry, 2018
The tuberous sclerosis complex (TSC) is a negative regulator of mTOR complex 1, a signaling node promoting cellular growth in response to various nutrients and growth factors.
J. Madigan, F. Hou, Linlei Ye, Jicheng Hu, A. Dong, W. Tempel, M. Yohe, P. Randazzo, L. Jenkins, M. Gottesman, Y. Tong   +10 more
semanticscholar   +1 more source

Expression of ICAM-1, TNF-α, NFκB, and MAP kinase in tubers of the tuberous sclerosis complex

Neurobiology of Disease, 2003
Individuals affected with tuberous sclerosis complex (TSC) develop cortical tubers characterized by disorganized cytoarchitecture and morphologically abnormal cell types, such as dysplastic neurons (DNs) and giant cells (GCs).
Michelle Maldonado, B.S., Marianna Baybis, M.A., David Newman, Dennis L Kolson, M.D., Ph.D., Wei Chen, Ph.D., Guy McKhann, II, David H Gutmann, M.D., Ph.D., Peter B Crino, M.D., Ph.D.   +7 more
doaj   +1 more source

Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death

Oncogene, 2018
Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction ...
Charlotte E. Johnson, E. Dunlop, Sara Seifan, H. McCann, T. Hay, Geraint J. Parfitt, Ashley T. Jones, Peter J. Giles, Ming H. Shen, Julian R. Sampson, Rachel J. Errington, D. M. Davies, Andrew R. Tee   +12 more
semanticscholar   +1 more source

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy. [PDF]

PLoS ONE, 2018
BACKGROUND:Hypoxemia in humans may occur during high altitude mountaineering and in patients suffering from ventilatory insufficiencies such as cardiovascular- or respiratory disease including Chronic Obstructive Pulmonary Disease (COPD).
C C de Theije, A M W J Schols, W H Lamers, D Neumann, S E Köhler, R C J Langen   +5 more
doaj   +1 more source

XBP-1s (spliced form of x-box binding protein-1) proteininin TSC (tuberous sclerosis complex) eksikliğinde insülin hassasiyetinin düzenlenmesindeki rolü

, 2021
İnsülin hassasiyetinin azalması, yani insülin direnci, Türkiye'de ve dünyada insan sağlığını tehdit eden obezite ve tip 2 diyabet gibi birçok metabolik bozukluğun altında yatan en önemli nedenlerden biridir. Beyin, böbrek ve deri gibi çeşitli organlarda selim tümörlere neden olan, otozomal dominant kalıtımlı tuberoz sklerozis (TSC) hastalığında da
openaire   +1 more source

Mechanosensitive molecular networks involved in transducing resistance exercise-signals into muscle protein accretion

Frontiers in Physiology, 2016
Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on ...
Emil Rindom, Emil Rindom, Kristian Vissing   +2 more
doaj   +1 more source

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis*

Journal of Biological Chemistry, 2016
Tuberous sclerosis complex (TSC) is caused by mutations in the TSC1 and TSC2 tumor suppressor genes. The gene products hamartin and tuberin form the TSC complex that acts as GTPase-activating protein for Rheb and negatively regulates the mammalian target
R. Zech, S. Kiontke, U. Mueller, Andrea Oeckinghaus, D. Kümmel   +4 more
semanticscholar   +1 more source

GSK-3β at the Crossroads in Regulating Protein Synthesis and Lipid Deposition in Zebrafish

Cells, 2019
In this study, the mechanism by which GSK-3β regulates protein synthesis and lipid deposition was investigated in zebrafish (Danio rerio). The vector of pEGFP-N1-GSK-3β was constructed and injected into the muscle of zebrafish.
Yaqi Gu, Lili Gao, Qiang Han, Ao Li, Hairui Yu, Dongwu Liu, Qiuxiang Pang   +6 more
doaj   +1 more source

The effect of a bout of resistance exercise on skeletal muscle protein metabolism after severe fasting

Physiological Reports, 2019
Resistance exercise (RE) activates the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway and increases muscle protein synthesis. Severe fasting induces 5′ adenosine monophosphate‐activated protein kinase (AMPK), which attenuates mTORC1
Kohei Sase, Kohei Kido, Satoru Ato, Satoshi Fujita   +3 more
doaj   +1 more source

Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter

Case Reports in Oncology, 2018
We evaluated the efficacy of everolimus in 3 patients who had huge renal angiomyolipomas associated with tuberous sclerosis complex. Two patients with large lipid-rich angiomyolipomas had a history of renal transarterial embolization for renal bleeding ...
Naoya Toriu, Hiroki Mizuno, Naoki Sawa, Keiichi Sumida, Tatsuya Suwabe, Noriko Hayami, Akinari Sekine, Masayuki Yamanouchi, Junichi Hoshino, Kenmei Takaichi, Motoko Yanagita, Takuya Fujimaru, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Yoshifumi Ubara   +15 more
doaj   +1 more source