Results 81 to 90 of about 18,558 (165)

TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis.

PLoS Biology, 2019
Dendritic cells (DCs) play pivotal roles in T-cell homeostasis and activation, and metabolic programing has been recently linked to DC development and function.
Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng, Jinbo Yang, Hui Xiao   +13 more
doaj   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Building a precision therapeutics program at a tertiary care children's hospital

Pediatric Investigation, EarlyView.
Luke Hamilton, Heidi Trinkman, Diana Carrasco, Kaitlin Smith, Kelly Vallance, Alejandra Dominguez, Danielle Miller, Megan Gibbs, Anish Ray   +8 more
wiley   +1 more source

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1530-1542, August 2026.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Immortalization of Adipose‐Derived Stromal Cells From Japanese Black Cattle

Cell Biology International, Volume 50, Issue 8, August 2026.
ABSTRACT Adipose tissue plays a critical role in determining the characteristic palatability of Japanese Black cattle beef, including its distinctive aroma, tenderness, and flavor. These quality traits are closely associated with adipogenic differentiation and lipid metabolism; however, the underlying molecular mechanisms remain poorly understood ...
Rei Sasaki, Hanami Matsukura, Ryo Meguro, Lanlan Bai, Ken Sawai, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono, Tomokazu Fukuda   +8 more
wiley   +1 more source

Integrated Immune, Epithelial and Lipid Pathways in NSAID‐Exacerbated Respiratory Disease

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT NSAID‐exacerbated respiratory disease (N‐ERD) is a chronic inflammatory disorder characterized by asthma, chronic rhinosinusitis with nasal polyps and respiratory reactions to cyclooxygenase‐1 inhibiting nonsteroidal anti‐inflammatory drugs (NSAID).
Piotr Szatkowski, Lucyna Mastalerz
wiley   +1 more source

The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid, Marin Golčić, Anja Harej Hrkać, Andrej Belančić   +3 more
wiley   +1 more source

Divergent skeletal muscle metabolite exchange in insulin‐like growth factor‐1‐stimulated myotubes and resistance‐exercised human muscle

Experimental Physiology, Volume 111, Issue 8, Page 3784-3799, 1 August 2026.
Abstract Skeletal muscle hypertrophy requires a substantial nutrient influx for biomass accretion, but global metabolite exchange during growth is poorly characterized. Therefore, we profiled the metabolite uptake and release in insulin‐like growth factor‐1 (IGF‐1)‐stimulated C2C12 myotubes and human muscle 24 h after resistance exercise ...
Tim Havers, Moritz Eggelbusch, Marius Meinhold, Kira Sing, Rainer Okrojek, Anna Artati, Michael Witting, Dominik Lutter, Claire V. Kieker, Collin Starke, Tushar More, Karsten Hiller, Flemming Dela, Martin Schönfelder, André Kafka, Stephan Geisler, Henning Wackerhage   +16 more
wiley   +1 more source

Mammalian target of rapamycin complex 1 (mTORC1); tuberous sclerosis complex tumor suppressors 1 and 2 (TSC1 and TSC2); unfolded protein response (UPR) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source